Abstract: Objective The using situation of antibacterials for patients in our hospital was retrospectively analyzed, in order to provide evidence for the rational use of antibacterials. Methods Distribution of pathogens, drug resistance rate and drug frequency (DDDs) of Gram-positive cocci and Gram-negative bacilli, the antibacterials use density (AUD) of patients from 2010 to 2012 in our hospital were retrospectively analyzed. Results 2 300 strains of bacteria were recorded in medical records, with 1 575 strains of Gram-negative bacilli (68.47%), 640 strains of Gram-positive cocci (27.83%), 85 strains of fungi (3.70%). Drug resistant rate of Gram-positive cocci was highly correlated with DDDs (R=0.827, P<0.05). Drug resistance rates of Gram-negative bacilli showed moderate correlation with DDDs, but the differences were not significant (R=0.568, P>0.05). The AUD of ceftriaxone, erythromycin and cefazolin between 2010~2012 ranked the top five consistently (2010: 5.03, 7.32, 2.33; 2011: 6.55, 4.01, 2.41; 2012: 5.13, 3.33, 3.01), the top five order of AUD for antibacterials had a few changes, and the AUD values declined in the three years. Conclusion The higher DDDs, the higher antibacterials resistance of pathogens, the antibacterials usage in our hospital was generally reasonable, but the rational use still needs to be further strengthened.

Key words: inpatient, antibacterials, retrospective analysis