Abstract: Objective To identify the patterns and characteristics of allergic reactions induced by oxaliplatin, and to explore prevention and treatment strategies in order to provide reference for clinical treatment. Methods The clinical data on forty-nine cases of allergic reactions induced by oxaliplatin was collected between January 2013 and December 2018.The general conditions of the patients, medication and the occurrence of allergic reactions were analyzed. Other cases of oxaliplatin-induced allergic reactions reported in literature were also reviewed. Results Allergic reactions induced by oxaliplatin can occur at any age and the median age was 52 years old. Males were more susceptible and the onset mostly occurred within 30 minutes. Most of the cases were of levels I-II. The median cumulative course of treatment was five,while the median cumulative dose was 636 mg. Thirty-one cases of oxaliplatin-induced allergic reactions were retrieved from literature. The most common symptom was hypotension, and there were even two unique cases of hypertensive crisis. Conclusion Hypertension crisis may be one of the oxaliplatin-induced allergic reactions that can be mitigated by reducing the rate of administration. In case of allergic reactions that cannot be avoided by reducing the rate of administration, changing the treatment regimen may be a better choice. Pretreatment may be an effective preventive measure. Allergic reactions caused by other chemotherapeutic drugs as well as infusion reactions should be distinguished from those induced by oxaliplatin.

Key words: oxaliplatin, allergic reaction, retrospective analysis, prevention strategy