Clinical Study on Compatibility of Sodium Nitroprusside for Injection and Sodium Chloride Injection after Prolonged Use to 26 h

Abstract

Abstract: Objective To provide scientific basis for clinical rational compatibility of sodium nitroprusside (SNP) for injection and sodium chloride (NS) injection. Methods The compatible solution of SNP and NS injection was given intravenously in three ways for the patients in 3 different groups of hypertensive crisis. The solution was given within 4 h, 12 to 14 h, and 24 to 26 h after preparation for each group of patients respectively. The blood contents of cyanide (CN) were measured, and blood gas analyses were performed at the same time, and the amounts of the SNP used were recorded. The contents of CN and the degradation of sodium nitroprusside in the compatible solution of SNP and NS injection were also measured 26 h after its preparation. Results As conventional preparation, the compatible solution of SNP and NS injection used within 26 h is safe and effective. Conclusion It is scientific to use the compatible solution of SNP and NS injection until 26 h after its preparation in clinic.

Key words: sodium nitroprusside, stability, cyanide, blood gas analysis

CLC Number:

R969.3

LIN Xiao-ming, HUANG Min, XIE Pei-de. Clinical Study on Compatibility of Sodium Nitroprusside for Injection and Sodium Chloride Injection after Prolonged Use to 26 h[J]. Chinese Journal of Pharmacovigilance, 2016, 13(5): 298-302.

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