Abstract: Objective Through researching the clinical application of 5-HT₃ antagonist in anesthesia patients, to analyze the rationality, which is aiming at establishing the regulation and system of clinical application of 5-HT₃ antagonist. Methods The clinical application research of 5-HT₃ and statistics analysis were conducted by reasearching 246 samples randomly through looking through their medical history. Results The research has further testified the effectiveness and safety of applying 5-HT₃ receptor anatagonist to prevent postoperative nausea and vomiting (PONV). The specific dose conforms to the principle of clinical drug use, which is to be safe and economical. It is recommended as follows: ondansetron hydrochoride injectgion 4 mg ~ 8 mg or granisetron hydrochloride injection 3 mg by intravenous injection during perioperative period. Conclusion This research proved that there was a relative higher proportion of applying 5-HT₃ receptor antagonist to prevent PONV among the participants. The research indicated that applying opioid drugs in most of the spine canal anesthesia was unnecessary, therefore, there was no necessity to apply serotonin receptor.

Key words: opioid analgesic, serotonin receptor antagonist, postoperative nausea and vomiting