Advances in Establishment of Animal Models with Hepatic Cirrhosis and Thinking about Efficacy Evaluation of Traditional Chinese Medicine

Abstract

Abstract: Objective To introduce the research development on the advances in establishment of animal models with hepatic cirrhosis and think about efficacy evaluation of traditional Chinese medicine (TCM). Methods The related references in the last decades at home and abroad about cirrhosis model were collated, analyzed and summarized. Results At present, single factor induced modeling and composite factors induced modeling were mainly two categories of the modeling scheme. Conclusion We should choose suitable animal model on the basis of TCM’s characteristic and combine the research of cirrhosis model with clinical disease closely, in order to screen and evaluate candidate drug, and offer methodological ensurance for TCM’s pharmacological preclinical research and efficacy evaluation at the same time.

Key words: hepatic cirrhosis, animal model, research progress

CLC Number:

R965

SHI Liang,SUN Rong. Advances in Establishment of Animal Models with Hepatic Cirrhosis and Thinking about Efficacy Evaluation of Traditional Chinese Medicine [J]. Chinese Journal of Pharmacovigilance, 2016, 13(1): 32-35.

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