Abstract: Objective To investigate the therapeutic effect of Lutongning granules to rat with Trigeminal neuralgia, and provide reference materials for the clinical applications. Methods Trigeminal neuralgia was made by chronic constriction injury of infraorbital nerve in rats. Rats were randomly divided into normal group, sham group, model group, carbamazepine group, Lutongning high dose group (2.70 g crude drug·kg^-1·d^-1) and Lutongning low dose group (1.35 g crude drug·kg^-1·d^-1). Von Frey Brush brush was used to detect the mechanical pain threshold of rat whisker pad, biochemical method was used to detect the coagulation and hemostream function, HE staining was used to observe the microcirculation change of the infraorbital nerve after perfusion, western blot was used to detect the p38 and p-p38 expression in the trigeminal nerve. Results Lutongning granulethe increased the pain threshold in model rats (P<0.05, P<0.01), reduced the plasma viscosity (P<0.05, P<0.01) and the whole blood reduction viscosity in model rats (P<0.05, P<0.01), improved the flow ability in model rats, increased PT, APTT and TT levels in model rats (P<0.05, P<0.01), reduced FIB levels (P<0.01), improved the microcirculation on the infraorbital nerve in the model rats, reduced the p-p38 expression in the trigeminal nerve of model rats (P<0.01). Conclusion Lutongning granules have the effect of improving trigeminal neuralgia, which may be related to the function of promoting blood circulation and removing blood stasis.

Key words: trigeminal neuralgia, chronic constriction injury of the infraorbital nerve, Lutongning granulethe, promoting blood circulation and removing blood stasis, trigeminal neuralgia, rat, carbamazepine