Chinese Journal of Pharmacovigilance ›› 2024, Vol. 21 ›› Issue (3): 355-360.
DOI: 10.19803/j.1672-8629.20220687

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Effect of sulfur fumigation on quality of Angelica dahurica and alternative processing methods in producing areas

WANG Changshun1,2, WANG Xiaolei1, DUAN Jiping1, YUAN Hao1, LIU Yongli1,*, ZHAO Ding2,#   

  1. 1Hebei Institute for Drug and Medical Device Control, NMPA Key Laboratory for Quality Monitoring and Evaluation of Traditional Chinese Medicine (Chinese Materia Medica), Shijiazhuang Hebei 050227, China;
    2Department of Pharmacognosy, Hebei Medical University, Shijiazhuang Hebei 050017, China
  • Received:2022-11-30 Online:2024-03-15 Published:2024-03-18

Abstract: Sulfur fumigation, as a processing and preservation method of traditional Chinese medicine in producing areas, is capable of insect control, mildew prevention, maintenance of bright color and acceleration of drying of traditional Chinese medicine. However, sulfur fumigation can also reduce the content of active ingredients in Chinese medicinal materials and transform them into new compounds while increasing the content of sulfur dioxide residue, heavy metals and harmful elements, which may reduce the efficacy but increase safety risks. Based on the literature available, this paper summarizes the impact of sulfur fumigation on the quality of Angelica dahurica and studies the processing methods in producing areas in order to provide reference for quality control of Angelica dahurica.

Key words: sulfur fumigation, A. dahurica, activity difference, quality control, processing in the producing area, pharmacological effect, adverse reactions

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