Analysis of one case of double knee joint pain induced by linezolid tablets

doi:10.19803/j.1672-8629.20220015

Abstract

Abstract: Objective To analyze new adverse reactions-double knee joint pain-caused by linezolid in order to provide reference for related clinical pharmaceutical care. Methods The causes of double knee joint pain in a 39-year-old female patient were analyzed who had suffered mycobacterium abscess infection after resection of intervertebral schwannoma and taken oral linezolid tablets 0.6 g, oral clarithromycin tablets 0.5 g, and oral moxifloxacin tablets 0.4 g. Drugs that might have caused joint pain were identified using the Naranjo’s assessment scale. Results The pain and discomfort of knee joint in both legs were attributed to linezolid, and considered new adverse reactions caused by linezolid. Conclusion Pharmacists should be alert to new adverse reactions caused by linezolid and give high-quality pharmaceutical care while watching out for such marrow suppression as leukopenia caused by linezolid.

Key words: linezolid, double knee joint, pain, adverse drug reactions, mycobacterium abscess, case report

CLC Number:

R994.11

WU Yanyan, HU Xuelian, DAN Chonghui. Analysis of one case of double knee joint pain induced by linezolid tablets[J]. Chinese Journal of Pharmacovigilance, 2023, 20(2): 221-224.

References

[1] Infectious Diseases Professional Committee of China Medical Education Association. Expert consensus on clinical application of pharmacokinetic/pharmacodynamic, PK/PD[J].Chinese Journal of Tuberculosis and Respiration(中华结核和呼吸杂志), 2018, 41(6): 409-446.
[2] CHEN F,ZHANG C,CUI M. Severe thrombocytopenia induced by linezolid injection: a case report[J]. Chinese Journal of Pharmacovigilance(中国药物警戒), 2017, 14(4): 254,256.
[3] HUNANG L, LU XH, LUO J.Literature analysis of 33 cases of thrombocytopenia induced by linezolid[J]. Chinese Journal of Pharmacovigilance(中国药物警戒), 2014, 11(5): 301-303.
[4] WANG L, BI HL.Leukopenia and drug fever induced by linezolid injection: a case report[J]. Chinese Journal of Pharmacovigilance(中国药物警戒), 2013, 10(2): 122-123.
[5] DONG HY, XIE J, CHEN LH, et al.Therapeutic drug monitoring and receiver operating characteristic curve prediction may reduce the development of linezolid-associated thrombocytopenia in critically ill patients[J]. Eur J Clin Microbiol Infect Dis, 2014, 33(6): 1029-1035.
[6] Tuberculosis Branch of Chinese Medical Association. Guidelines for the diagnosis and treatment of non-tuberculous mycobacteriosis (2020)[J].Chinese Journal of Tuberculosis and Respiration(中华结核和呼吸杂志), 2020, 43(11): 918-946.
[7] AGYEMAN AA, OFORI-ASENSO R.Efficacy and safety profile of linezolid in the treatment of multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis: a systematic review and meta-analysis[J]. Ann Clin Microbiol Antimicrob, 2016, 15(1): 41.
[8] LEE M, LEE J, CARROLL MW, et al.Linezolid for treatment of chronic extensively drug-resistant tuberculosis[J]. N Engl J Med, 2012, 367(16): 1508-1518.
[9] THIROT H, BRIQUET C, FRIPPIAT F, et al.Clinical use and adverse drug reactions of linezolid: a retrospective study in four belgian hospital centers[J]. Antibiotics (Basel), 2021, 10(5): 530.
[10] GUAN YH, LIN WN. Adverse reaction analysis of 118 cases of linezolid[J]. Northern Pharmacy(北方药学), 2020, 17(11): 40, 63.
[11] REN J, DU H, ZHENG Y, et al.Black tongue induced by linezolid: a report of 3 cases[J].Journal of Pharmacoepidemiology(药物流行病学杂志), 2020, 29(4): 291-292.
[12] ZHANG B, GAO DL, ZHAO S, et al.Analysis of reported cases of black tongue and hairy tongue induced by linezolid[J].Journal of Pharmacoepidemiology(药物流行病学杂志), 2021, 3: 210-214.
[13] REN J, ZHENG Y, DU H, et al.Antibiotic-induced black hairy tongue: two case reports and a review of the literature[J]. J Int Med Res, 2020, 48(10): 300060520961279.
[14] JAIN AK, PURI MM, SARIN R.Black brown discoloration and hairy tongue - A rare linezolid side effect[J]. Indian J Tuberc, 2017, 64(1): 44-46.
[15] LUO S, LUO Q, GAO X, et al.Adverse reaction report and retrospective analysis of black hairy tongue caused by linezolid[J]. Respir Med Case Rep, 2020, 31: 101159.
[16] BRAGGIO C, BOCCHIALINI G, VENTURA L, et al.Linezolid-induced black hairy tongue[J]. Acta Biomed, 2018, 89(3):408-410.
[17] BALAJI G, MAHARANI B, RAVICHANDRAN V, et al.Linezolid induced black hairy tongue[J]. Indian J Pharmacol, 2014, 46(6): 653-654.
[18] BOUNTHAVONG M, HSU DI.Efficacy and safety of linezolid in methicillin-resistant Staphylococcus aureus (MRSA) complicated skin and soft tissue infection (cSSTI): a meta-analysis[J]. Curr Med Res Opin, 2010, 26(2): 407-421.
[19] THAI XC, BRUNO-MURTHA LA.Bell’s palsy associated with linezolid therapy: case report and review of neuropathic adverse events[J]. Pharmacotherapy, 2006, 26(8): 1183-1189.
[20] VISWANATHAN P, IARIKOV D, WASSEL R, et al.Hypoglycemia in patients treated with linezolid[J]. Clin Infect Dis,2014, 59(8): e93-95.
[21] WANG HX, LU XF.Diagnostics(诊断学)[M]. 9th ed. Beijing: People’s Medical Publishing House, 2018.
[22] ATS, ERS, ESCMID, et al. Treatment of Nontuberculous Mycobacterial Pulmonary Disease: An Official ATS/ERS/ESCMID/IDSA Clinical Practice Guideline: Executive Summary[J]. Clin Infect Dis, 2020(6): ciaa241.
[23] ZHENG FY, WU Y, RAO YF, et al.The role and case analysis of Naranjo’s assessment scale in the evaluation of adverse drug reactions[J].Chinese Journal of Pharmacy(中国药学杂志), 2012, 47(8): 650-652.
[24] WAN L, ZHAO Q, CHEN J, et al.Chinese expert consensus on the application of pain assessment scale (2020 edition)[J].Chinese Journal of Pain(中华疼痛学杂志), 2020, 16(3): 177-187.
[25] MANDOVRA NP, LELE TT, VAIDYA PJ, et al.High incidence of new-onset joint pain in patients on fluoroquinolones as antituberculous treatment[J]. Respiration, 2020, 99(2): 125-131.
[26] VALENT P, KLION AD, HORNY HP, et al. Contemporary consensus proposal on criteria and classification of eosinophilic disorders and related syndromes[J]. J Allergy Clin Immunol, 2012, 130(3): 607-612.e9.
[27] YASUI-FURUKORI N, SATO Y, KATO H, et al.Paroxetine-associated hypereosinophilia may clinically resemble a panic attack[J]. Clin Neuropharmacol, 2012, 35(1): 47-48.
[28] VARGA J, UITTO J, JIMENEZ SA.The cause and pathogenesis of the eosinophilia-myalgia syndrome[J]. Ann Intern Med, 1992, 116(2): 140-147.
[29] LING F.Levofloxacin induces joint swelling and pain[J]. Journal of Adverse Drug Reaction, 2005, 7(2): 137-138.
[30] LIU Y.Rash and joint swelling and pain induced by mizolastine: a case report[J]. Herald of Medicine(医药导报), 2010, 29(12): 1647.
[31] ZHABG XY.Joint and muscle pain caused by Rifampicin:a case report[J].Chinese Journal of Tuberculosis(中国防痨杂志), 2010, 32(6): 342.
[32] WANG ST, ZHAO YM.Joint pain induced by harringtonine injection:a report of 2 cases[J]. Chinese Journal of Pharmacovigilance(中国药物警戒), 2010, 7(12): 761.