Safety and efficacy of participation of pharmacists in warfarin anticoagulation therapy：a Meta-analysis

doi:10.19803/j.1672-8629.2022.09.16

Abstract

Abstract: Objective To assess the impact of the pharmacist-managed anticoagulant therapy on clinical outcomes compared with other models. Methods PubMed, Embase and Cochrane Library were searched for related literature published from inception to April 13, 2020. The pharmacist-led anticoagulation model was compared and contrasted with doctor- or nurse-led anticoagulation models. Endpoint events included the percentage of time within the target therapeutic range (TTR), bleeding events, and thrombotic events. Results A total of 23 studies involving 10 772 patients were included. The pharmacist-managed anticoagulation model could significantly reduce total bleeding and the incidence of minor bleeding and thrombosis compared with other models. According to sub-set analysis by types of intervention, the pharmacist-led group could reduce total bleeding and the incidence of minor bleeding and thrombosis more significantly than the physician-led group. Conclusion The pharmacist-managed anticoagulation model is safer and more effective than other anticoagulation models.

Key words: warfarin, anticoagulants, pharmacist, anticoagulation model, Meta-analysis

CLC Number:

R996

WEN Dusu, SUN Jianjun, WANG Yi. Safety and efficacy of participation of pharmacists in warfarin anticoagulation therapy：a Meta-analysis[J]. Chinese Journal of Pharmacovigilance, 2022, 19(9): 1009-1014.

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