Effect and safety of sacubatril/valsartan sodium in the treatment of hypertension: a Meta-analysis

doi:10.19803/j.1672-8629.20210154

Abstract

Abstract: Objective To evaluate the difference in effect and safety of sacubitril/valsartan sodium and angiotensin receptor blockers (ARB) in the treatment of hypertension. Methods Data on randomized controlled trials (RCT) of sacubatril/valsartan sodium (test group) versus angiotensin II receptor antagonist (ARB) (control group) was retrieved from PubMed, Embase, Medline, Cochrane Library , CNKI, Wanfang Database published from inception to October 20, 2020. The quality of the included literature was evaluated using the bias risk assessment tool recommended by Cochrane System Reviewer Manual 5.2.2, and the RevMan 5.3 software was used for Meta analysis. Results Eight RCT were included, involving 4 313 patients. Compared with ARB, sacubatril/valsartan sodium could more effectively reduce systolic blood pressure (msSBP), diastolic blood pressure (msDBP), ambulatory systolic blood pressure (maSBP) and ambulatory diastolic blood pressure(maDBP). Sacubatril/valsartan sodium was basically as safe as ARB, but was more likely to cause cough. Conclusion sacubatril/valsartan sodium can significantly reduce blood pressure of patients with hypertension, but clinicians should be alert to any cough caused by this drug.

Key words: sacubatril/valsartan sodium, hypertension, angiotensin receptor blockers, Meta-analysis.

CLC Number:

R972.4

ZHENG Li, ZHANG Xuqian, SUN Xuelin, DING Huihua. Effect and safety of sacubatril/valsartan sodium in the treatment of hypertension: a Meta-analysis[J]. Chinese Journal of Pharmacovigilance, 2022, 19(10): 1118-1122.

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