Abstract: Objective To find out about the clinical profiles and targeted diseases of Linggui Zhugan decoction in order to provide reference for the development and application of Linggui Zhugan decoction and to inspire ideas for modern clinical applications of other classical prescriptions. Methods Related literature that was published between January 1, 1979 and February 11, 2020 was searched for from CNKI, VIP, Wanfang and other databases, Excel 2010 was used to sort out and statistically analyze such key information as the indications, number of cases, composition of medicine, characteristics of prescriptions, dosage, usage, efficacy and adverse reactions. The clinical applicability and targeted diseases of Linggui Zhugan decoction were studied based on data. Results A total of 543 pieces of literature met the inclusion criteria. It was found that Linggui Zhugan decoction was used against various indications, the number of cases ranged from 50 to 99, the total effective rate was over 90% and that few adverse reactions occurred. Heart failure was one of the targeted diseases of this decoction and the composition of this decoration was still based on the original prescription. The dosage varied considerably. This decoration was prepared by boiling the ingredients in water. 100-200 mL was taken each time, two or three times a day. Other herbs, which could benefit qi, activate blood and facilitate urination, were added. Conclusion This paper is expected to provide clinical data for more extensive use of Linggui Zhugan decoction and guide its industrialized clinical application.

Key words: classical formulas, Linggui Zhugan decoction, modern clinical practice, targeted diseases, heart failure