中国药物警戒 ›› 2012, Vol. 9 ›› Issue (3): 178-180.

• 药品不良反应监测 • 上一篇    下一篇

头孢曲松钠致过敏性休克97例文献分析

王静芬1，苏利群2   

  1. 1 广东省潮州卫生学校，广东 潮州 521000；
    2 潮州港经济开发区管委会，广东 潮州 515700
  • 收稿日期:2011-06-17 出版日期:2012-03-10 发布日期:2015-08-10
  • 通讯作者: 苏利群,男,临床药理学。E-mail：suliqun@tom.com
  • 作者简介:王静芬，女，高级讲师，护理学。

Literature Analysis of 97 Case Reports of Anaphylactic Shock Induced by Ceftriaxone Sodium

WANG Jing-fen1, SU Li-qun2   

  1. 1 Chaozhou Health School of Guangdong Province, Guangdong Chaozhou 521000, China;
    2 Management Committee of Chaozhou Port Economic Development Zone, Guangdong Chaozhou 515700, China
  • Received:2011-06-17 Online:2012-03-10 Published:2015-08-10

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摘要： 目的探讨头孢曲松钠致过敏性休克的特点和规律，为临床安全用药提供参考。方法对2001~2010年国内公开发表文献中，有关头孢曲松钠致过敏性休克97例个案报道进行回顾性分析。结果有87.6%的过敏性休克发生在首次用药过程中，67.1%发生在用药后的10min内，死亡率达到18.6%;头孢曲松钠存在滥用和不合理用药等问题。结论应高度重视头孢曲松钠的合理使用，密切观察并及时抢救过敏性休克。

关键词: 头孢曲松钠, 不良反应, 过敏性休克

Abstract: Objective To investigate the characteristics and regularities of anaphylactic shock induced by ceftriaxone sodium and provide the clinical reference of the drug safety. MethodsData were collected from domestic published literatures between 2001 to 2010 and 97 case reports of anaphylactic shock induced by Ceftriaxone Sodium were analyzed retrospectively.Results87.6% of anaphylactic shock occurred in the first time use of Ceftriaxone Sodium and 67.1% of the reaction happened within 10 minutes of drug administration.The mortality rate of anaphylactic shock by Ceftriaxone Sodium were 18.6%. Clinical overuse and irrational combination of Ceftriaxone Sodium were found. ConclusionRational use of Ceftriaxone Sodium is important. Close observation of drug reaction and well preparation for anaphylactic shock are recommended.

Key words: ceftriaxone sodium, adverse drug reaction, anaphylactic shock