中国药物警戒 ›› 2023, Vol. 20 ›› Issue (11): 1290-1292.
DOI: 10.19803/j.1672-8629.20220492

• 安全与合理用药 • 上一篇    下一篇

华法林片联合复方氨酚烷胺片致凝血功能极度异常1例分析

张雯雯1, 聂西庭2, 徐会茹3, 冉晔2,*, 田成林2, 于生元2   

  1. 1南开大学医学院,天津 300071;
    2解放军总医院第一医学中心神经内科,北京 100853;
    3淄博市张店区人民医院神经内科,山东 淄博 255000
  • 收稿日期:2022-08-18 出版日期:2023-11-15 发布日期:2023-11-13
  • 通讯作者: *冉晔,男,博士,主治医师,神经病学。E-mail: ranyenk@126.com
  • 作者简介:张雯雯,女,在读硕士,神经病学。
  • 基金资助:
    军队后勤科研重点项目（20BJZ38）

One case of extremely abnormal coagulation caused by warfarin combined with compound paracetamol and amantadine hydrochloride tablets

ZHANG Wenwen1, NIE Xiting2, XU Huiru3, RAN Ye2,*, TIAN Chenglin2, YU Shengyuan2   

  1. 1School of Medicine, Nankai University, Tianjin 300017, China;
    2Department of Neurology, the First Medical Center of Chinese PLA General Hospital, Beijing 100853, China;
    3Department of Neurology, Zhangdian People’s Hospital of Zibo, Zibo Shandong 255000, China
  • Received:2022-08-18 Online:2023-11-15 Published:2023-11-13

PDF (PC)

107

摘要： 目的 探讨华法林片与复方氨酚烷胺片可能存在的不良药物相互作用。方法 报道1例因静脉窦血栓而长期服用华法林的患者,间断服用复方氨酚烷胺片后出现凝血功能持续极度异常。结果 患者经停用华法林、补充维生素K及凝血因子后凝血功能逐渐恢复。结论 复方氨酚烷胺片或可明显增强华法林的抗凝效果,导致极高的出血风险,临床诊疗中需注意两药相互作用所致的不良反应,应谨慎合用,需密切观察出血情况和监测凝血功能。

关键词: 华法林, 复方氨酚烷胺, 凝血功能, 抗凝, 药品不良反应, 药物相互作用

Abstract: Objective To explore the possible adverse drug interactions between warfarin and compound paracetamol and amantadine hydrochloride tablets. Methods A patient who had been taking warfarin for a long time for venous sinus thrombosis was reported to have sustained extremely abnormal coagulation function after intermittent administration of compound paracetamol and amantadine hydrochloride tablets. Results The coagulation function of the patient recovered gradually after discontinuation of warfarin and supplementation of vitamin K and coagulation factors. Conclusion Compound paracetamol and amantadine hydrochloride tablets may significantly enhance the anticoagulant effect of warfarin, leading to an extremely high risk of bleeding. Clinicians should be alert to the interactions between the two drugs. Warfarin and cold medicine must be cautiously combined in clinical treatment, and bleeding and clotting function should be closely monitored.

Key words: warfarin, compound paracetamol and amantadine hydrochloride tablets, coagulation function, anticoagulation, adverse drug reaction, drug interaction

中图分类号: