中国药物警戒 ›› 2023, Vol. 20 ›› Issue (5): 588-590.
DOI: 10.19803/j.1672-8629.20220368

• 安全与合理用药 • 上一篇    下一篇

疑似注射用哌拉西林钠舒巴坦钠致尿毒症血液透析患者精神异常1例分析

张志文1, 唐莉华2   

  1. 1江西省中西医结合医院肾内科,江西 南昌 330003;
    2江西省中西医结合医院药剂科,江西 南昌 330003
  • 收稿日期:2022-07-04 出版日期:2023-05-15 发布日期:2023-05-16
  • 作者简介:张志文,男,硕士,主治医师,中西医结合。

Suspected mental disorder in uremia hemodialysis induced by piperacillin sodium and sulbactam sodium for injection: a case report

ZHANG Zhiwen1, TANG Lihua2   

  1. 1Department of Nephrology,Jiangxi Province Hospital of Integrated Chinese and Western Medicine, Nanchang Jiangxi 330003, China;
    2Department of Pharmacy, Jiangxi Province Hospital of Integrated Chinese and Western Medicine, Nanchang Jiangxi 330003, China
  • Received:2022-07-04 Online:2023-05-15 Published:2023-05-16

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摘要： 目的 为血液透析患者应用β-内酰胺类药物的安全性提供参考。方法 分析1例规律血液透析患者应用注射用哌拉西林钠舒巴坦钠致精神异常的病例,评估药品不良反应发生的可能因素与用药安全性。结果 此次药品不良反应与注射用哌拉西林钠舒巴坦钠可能有关,经停药和对症处理后,患者未再出现精神异常。结论 肾功能异常患者临床应用注射用哌拉西林钠舒巴坦钠时,需根据内生肌酐清除率(Ccr值)调整给药剂量或给药间隔,以确保临床用药的安全性和有效性,同时警惕中枢神经系统相关严重不良反应的发生。

关键词: 哌拉西林钠舒巴坦钠, 药品不良反应, 尿毒症, 精神异常, 血液透析

Abstract: Objective To provide reference for safe use of β-lactam in hemodialysis patients. Methods A case of mental abnormality caused by piperacillin sodium and sulbactam sodium for injection in a regular hemodialysis patient was retrospectively analyzed to find out about the possible causes of adverse drug reactions and the safety of medication. Results The adverse drug reactions might have involved piperacillin sodium and sulbactam sodium for injection. After drug withdrawal and symptomatic treatment, the patient developed no more mental abnormalities. Conclusion The dose or interval of piperacillin sodium and sulbactam sodium for injection should be adjusted according to the endogenous creatinine clearance(Ccr) to ensure the safety and efficacy of medications. Clinicians should be alert to serious adverse reactions related to the central nervous system.

Key words: piperacillin sodium and sulbactam sodium, adverse drug reaction, uremia, mental disorder, hemodialysis

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