单纯疱疹病毒I型与阿尔茨海默病相关性及中药抗单纯疱疹病毒I型感染研究进展

doi:10.19803/j.1672-8629.20220363

摘要/Abstract

摘要： 目的对单纯疱疹病毒I型（herpes simplex virus type I, HSV-1）与阿尔茨海默病（alzheimer's disease, AD）的病理关系、可能机制及中药抗HSV-1感染研究进行综述。方法检索CNKI和PubMed数据库,收集1990年1月1日至2022年5月30日中医、西医关于HSV-1与阿尔茨海默病关系研究及中药防治HSV-1研究的报道。结果 HSV-1反复感染可诱导β淀粉样蛋白（β amyloid, Aβ）累积和微管相关蛋白磷酸化（Tau protein phosphorylation, p-Tau）表达增加;ApoE4基因有利于HSV-1进入大脑增加HSV-1诱发AD的风险,Aβ可能是一种诱捕HSV-1的抗菌肽;研究发现多种中药单体或复方具有较好的抗HSV-1作用。结论 HSV-1感染可能是阿尔茨海默病发生发展的因素之一,其机制可能与Aβ诱捕HSV-1病毒有关,ApoE4基因增加了HSV-1诱发AD的风险,目前中药抗HSV-1感染研究已取得了一定进展,为从中药筛选抗HSV-1新药提供了有力支撑。

关键词: 单纯疱疹病毒I型, 阿尔茨海默病, 中药, 免疫系统, 神经系统, 感染

Abstract: Objective To review the pathological association between herpes simplex virus type I (HSV-1) and Alzheimer’s disease (AD), the possible mechanism and the role of traditional Chinese medicines in anti-HSV-1 infection. Methods CNKI and PubMed databases were searched for reports on the relationships between HSV-1 and Alzheimer’s disease and on the prevention and treatment of HSV-1 with traditional Chinese medicines and Western medicine that were published between January 1, 1990 and May 30, 2022. Results It was found that repeated HSV-1 infections induced the accumulation of β amyloid (Aβ) and the increase of p-Tau expressions. ApoE? gene facilitated the entry of HSV-1 into the brain and increased the risk of AD induced by HSV-1. Aβ might be an antimicrobial peptide that trapped HSV-1. Many of the monomers or compounds of traditional Chinese medicines had good anti-HSV-1 effect. Conclusion HSV-1 infection maybe one of the factors for the development of Alzheimer’s disease, and the mechanism may be related to the trapping of HSV-1 virus by Aβ. ApoE? gene increases the risk of HSV-1 induced Alzheimer’s disease. Some progress has been made in the study on anti-HSV-1 infection by traditional Chinese medicines, which provides strong support for screening new drugs against HSV-1 from traditional Chinese medicines.

Key words: herpes simplex virus-1, Alzheimer's disease, traditional Chinese medicine, immunologic system, nervous system, infection

中图分类号:

李舒冉, 郭姗姗, 崔晓兰. 单纯疱疹病毒I型与阿尔茨海默病相关性及中药抗单纯疱疹病毒I型感染研究进展[J]. 中国药物警戒, 2023, 20(3): 258-261.

LI Shuran, GUO Shanshan, CUI Xiaolan. Research progress in correlations between herpes simplex virus-1 and Alzheimer's disease and in the prevention and treatment of herpes simplex virus-1 with traditional Chinese medicine[J]. Chinese Journal of Pharmacovigilance, 2023, 20(3): 258-261.

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