榄香烯乳状注射液治疗脑瘤人群临床特征及联合用药的复杂网络分析

doi:10.19803/j.1672-8629.2022.09.04

摘要/Abstract

摘要： 目的探讨榄香烯乳状注射液治疗脑瘤人群的临床特征及联合用药情况,为临床治疗脑瘤的联合用药方案及用药安全性、疗效性、科学性提供参考。方法选取全国21家医院信息系统（HIS）数据库2003年1月1日至2019年7月31日使用榄香烯乳状注射液治疗502例脑瘤患者的临床信息,对患者的基本信息、中西医诊断及联合用药等进行分析;基于Louvain聚类方法对联合用药的复杂网络进行分析,探索治愈或好转的脑瘤患者使用榄香烯乳状注射液与其他中西药之间联合用药使用情况。结果患者平均年龄50.4岁,男女性别比例相对均衡;入院方式主要来自门诊,多为放疗中心;治愈和好转患者核心联用药物中,榄香烯乳状注射液常与甘露醇、肝素类、地塞米松、胸腺肽、氯化钾、维生素、复方苦参注射液、利多卡因、甘油联合应用。结论榄香烯乳状注射液联合用药对脑瘤疾病的治疗有其规律可循且疗效明显;在安全性方面,榄香烯乳状注射液不会增加其不良反应发生。

关键词: 榄香烯乳状注射液, 脑瘤, 真实世界, 临床特征, Louvain聚类方法, 复杂网络分析

Abstract: Objective To investigate the clinical characteristics and combined drug use of elemene emulsion injection in the treatment of brain tumors so as to help ensure the safety and efficacy of related medications. Methods The clinical information about 502 patients with brain tumors treated with elemene emulsion injection was collected from the database of the hospital information system (HIS) of twenty-one hospitals between January 1, 2003 and July 31, 2019. Statistical methods were used to analyze the basic information on these patients, such as gender, age, admissions, condition, length of hospital stay, diagnosis by TCM and western medicine, and combined medications. The complex network of combined medications was analyzed using the Louvain clustering method to explore how elemene emulsion injection was used in combination with other traditional Chinese medicines or Western medicines among brain tumor patients who had been cured or improved. Results The average age of these patients was 50.4, and there were almost as many male patients as female ones. Most of the hospitalizations were related to radiotherapy centers. Elemene emulsion injection was often used together with mannitol, heparins, dexamethasone, thymosin, potassium chloride, vitamins, compound matrine injection, lidocaine and glycerol. Conclusion There are some regularities in the way elemene emulsion injection is used in combination with other drugs. This drug is effective for brain tumors and is unlikely to increase the chance of adverse reactions.

Key words: elemene emulsion injection, brain tumor, the real world, clinical characteristics, Louvain clustering method, complex network analysis

中图分类号:

谭畅, 赵晓晓, 支英杰, 王连心, 谢雁鸣. 榄香烯乳状注射液治疗脑瘤人群临床特征及联合用药的复杂网络分析[J]. 中国药物警戒, 2022, 19(9): 947-953.

TAN Chang, ZHAO Xiaoxiao, ZHI Yingjie, WANG Lianxin, XIE Yanming. Clinical characteristics and combined medications of elemene emulsion injection in the treatment of brain tumors[J]. Chinese Journal of Pharmacovigilance, 2022, 19(9): 947-953.

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