何首乌肝毒性物质基础研究进展

doi:10.19803/j.1672-8629.2022.06.06

摘要/Abstract

摘要： 目的分析何首乌致肝损伤相关报道,讨论其致肝毒性的物质基础。方法通过查阅中国知网、万方数据、维普网、PubMed和Web of Science等数据库,对近25年来报道何首乌肝损伤的潜在肝毒性成分进行回顾性研究。结果何首乌中蒽醌类、二苯乙烯类、萘类成分及真菌毒素等可能是其诱发“固有肝毒性”“特异质肝毒性”“协同作用致肝毒性”“外源污染物致肝毒性”的主要物质基础。结论何首乌致肝损伤的物质基础较复杂,有必要进一步对其不同类型化学成分进行急性毒性及肝毒性作用机制研究,以期为何首乌肝毒性研究提供参考,并为其临床合理用药提供建议。

关键词: 何首乌, 固有肝毒性, 物质基础, 特异质肝毒性, 协同作用致肝毒性, 外源污染物致肝毒性

Abstract: Objective To analyze the material basis of liver toxicity of Polygonum multiflorum Thunb. based on related reports about the risk of liver injury caused by P. multiflorum. Methods Such databases as CNKI, Wangfang, VIP, PubMed and Web of Science were searched for literature related to the potentially hepatotoxic components of P. multiflorum reported over the past 25 years. Results Anthraquinones, stilbenes, naphthalene, mycotoxins from P. multiflorum might be the major hepatotoxic components that resulted in the "inherent hepatotoxicity" "idiosyncracy hepatotoxicity" "synergistic hepatotoxicity" and "liver toxicity caused by exogenous contaminants". Conclusion The material basis of liver injury caused by P. multiflorum is so complicated that the acute toxicity and mechanism of liver injury of these components need to be further studied in order to provide reference for the research on the hepatotoxicity of P. multiflorum and for rational use of P. multiflorum in clinic.

Key words: Polygonum multiflorum Thumb. inherent hepatotoxicity, material basis, idiosyncracy hepatotoxicity, synergistic hepatotoxicity, liver toxicity caused by exogenous contaminants

中图分类号:

R961
R969.3

杨建波, 高博闻, 孙华, 靳洪涛, 高慧宇, 牛慧, 程显隆, 王雪婷, 宋云飞, 魏锋, 汪祺, 王莹, 胡笑文, 马双成. 何首乌肝毒性物质基础研究进展[J]. 中国药物警戒, 2022, 19(6): 610-614.

YANG Jianbo, GAO Bowen, SUN Hua, JIN Hongtao, GAO Huiyu, NIU Hui, CHENG Xianlong, WANG Xueting, SONG Yunfei, WEI Feng, WANG Qi, WANG Ying, HU Xiaowen, MA Shuangcheng. Research progress on material basis of liver toxicity of Polygonum multiflorum Thunb.[J]. Chinese Journal of Pharmacovigilance, 2022, 19(6): 610-614.

参考文献

[1] State Pharmacopoeia Commission.Pharmacopoeia of the People's Republic of China, Volume I, 2020 edition(中华人民共和国药典,第一卷,2020年版)[M]. Beijing: China Medical Science and Technology Press, 2020:183-184.
[2] HAN ZX, TU C, GE FL, et al.Processing-related differences of Polygoni Multiflori Radix and its preparations-induced liver injury based on reports[J]. Chinese Journal of Pharmacoepidemiology(药物流行病学杂志), 2019, 28(4): 227-258.
[3] LI CY, LI XF, TU C, et al.The idiosyncratic hepatotoxicity of Polygonum multiflorum based on endotoxin model[J]. Acta Pharma-ceutica Sinica(药学学报), 2015, 50(1): 28-33.
[4] CHANG YL, LI N.Systematic review of drug-induced liver injury caused by Polygonum Multiflorum and its preparations[J]. China Pharmaceuticals(中国药业), 2020, 29(19): 81-86.
[5] WANG WR, HONG B, SHAN GS.Research progress on mechanism of hepatotoxicity of Ploygoni Multiflori Radix[J]. Drugs & Clinic(现代药物与临床), 2020, 35(2): 378-382.
[6] BUT PP, TOMLINSON B, LEE KL.Hepatitis related to the Chinese medicine Shou-wu-pian manufactured from Polygonum multiflorum[J]. Veterinary and Human Toxicology, 1996, 38(4): 280-282.
[7] MAZZANTI G, BATTINELLI L, DANIELE C, et al.New case of acute hepatitis following the consuming of Shouwupian, a Chinese herbal product derived from Polygonum multiflorum[J]. Annals of Internal Medicine, 2004, 140(7): W30.
[8] YU HL, YU DM, SONG HB, et al.Literature study on adverse drug reactions and analysis of risk factors of Polygonum multiflorum Thunb. and its common preparations[J]. Chinese Journal of Pharmacovigilance(中国药物警戒), 2018, 15(8): 470-475.
[9] CFDA. Notice of the general office of the State Food and Drug Administration on revising the instructions of six oral preparations containing Radix Polygoni Multiflori including Yangxue Shengfa capsule[EB/OL]. (2013-10-23)[2021-07-12]. http:// samr.cfda.gov.cn/WS01/CL1706/93676.html.
[10] CFDA. Notice of the general office of the State Food and Drug Administration on strengthening the supervision of health food containing Polygonum multiflorum[EB/OL]. (2014-07-09)[2021-07-12]. http://www.nmpa.gov.cn.
[11] WANG H, YANG J, ZHOU LY, et al.Chemical compositions and pharmacological activities of Polygoni Multiflori Radix[J]. Chinese Journal of Experimental Traditional Medical Formulae(中国实验方剂学杂志), 2019, 25(13): 192-205.
[12] MA J, ZHENG L, HE YS, et al.Hepatotoxic assessment of Polygoni multiflora radix extract and toxicokinetic study of stilbene glucoside and anthraquinones in rats[J]. Journal of Ethnopharmacology, 2015, 162: 61-68.
[13] QUAN YY.Investigation on the hepatotoxic material basis and mechanism of Polygoni Multiflori Radix with zebrafish (Danio rerio) model[D]. Chengdu: Chengdu University of Traditional Chinese Medicine, 2019.
[14] ZHANG M, LIN L, LIN H, et al.Interpretation the hepatotoxicity based on pharmacokinetics investigated through oral administrated different extraction parts of Polygonum multiflorum on rats[J]. Frontiers in Pharmacology, 2018, 9: 505.
[15] WANG X, HAN L, BI Y, et al.Paradoxical effects of emodin on anit-induced intrahepatic cholestasis and herb-induced hepatotoxicity in mice[J]. Toxicological Sciences, 2019, 168(1): 264-278.
[16] YAN Y, SHI N, HAN X, et al.UPLC/MS/MS-based metabolomics study of the hepatotoxicity and nephrotoxicity in rats induced by Polygonum multiflorum Thunb.[J]. ACS Omega, 2020, 5(18): 10489-10500.
[17] YAN YJ, WEN HR, DAN M, et al.Effects of three Polygonum multiflorum monomers on liver injury in rats[J]. Modern Chinese Medicine(中国现代中药), 2019, 21(8): 1054-1061.
[18] HU XQ, ZHOU J, LI YL, et al.Effects of stilbene glucoside from Polygonum multiflorum Thunb. on hepatic enzymes and serum albumin of rats[J]. Liaoning Journal of Traditional Chinese Medicine(辽宁中医杂志), 2011, 38(5): 988-990.
[19] WU XQ, CHEN XZ, HUANG QC, et al.Toxicity of raw and processed roots of Polygonum multiflorum[J]. Fitoterapia, 2012, 83(3):469-475.
[20] YAN YJ, DAN M, WANG Q, et al.Hepatotoxicity evaluation of Polygonum Multiflorum based on 2D and 3D hepatocyte models in vitro[J]. Chinese Journal of Pharmacovigilance(中国药物警戒), 2019, 16(7): 385-392.
[21] LIN P, LU JM, ZHANG GY, et al.Study on absorption and metabolism of active compounds of Polygoni Multiflori radix in hepatic L-02 cells by liquid chromatography tandem-mass spectrometry[J]. Chinese Pharmaceutical Journal(中国药学杂志), 2015, 50(12): 1048-1053.
[22] WANG Q, WANG Y, LI Y, et al.Identification and characterization of the structure-activity relationships involved in UGT1A1 inhibition by anthraquinone and dianthrone constituents of Polygonum multiflorum[J]. Scientific Reports, 2017, 7(1): 17952.
[23] LI HY, YANG JB, LI WF, et al.In vivo hepatotoxicity screening of different extracts, components, and constituents of Polygoni Multiflori Thunb. in zebrafish (Danio rerio) larvae[J]. Biomedicine & Pharmacotherapy, 2020, 131: 110524.
[24] WU Y.Chinese society of toxicology proceedings of the first academic exchange conference of Chinese medicine and natural drug toxicology Professional Committee of Chinese society of toxicology(中国毒理学会中药与天然药物毒理专业委员会第一次学术交流大会论文集)[C]. Tianjin: Chinese Medicine and Natural Drug Toxicology Professional Committee of Chinese Society of Toxicology, 2016.
[25] SONG J, MA ZJ, WANG JB, et al.Effects of Polygonum multiflorum Thunb. and its main components on normal people L02 hepatocyte study on the damage effect[J]. Beijing Journal of Traditional Chinese Medicine(北京中医药), 2016, 35(7): 694-697.
[26] HAN L, WANG P, WANG Y, et al.Rapid discovery of the potential toxic compounds in Polygonum multiflorum by UHPLC/Q-Orbitrap-MS-Based metabolomics and correlation analysis[J]. Frontiers in Pharmacology, 2019, 10: 329.
[27] YANG JB, LI WF, LIU Y, et al.Acute toxicity screening of different extractions, components and constituents of Polygonum multiflorum Thunb. on zebrafish (Danio rerio) embryos in vivo[J]. Biomedicine & Pharmacotherapy, 2018, 99: 205-213.
[28] LI CY.Preliminary study on heterogeneous liver injury of Polygonum multiflorum Thunb. based on immune stress[D]. Chengdu: Chengdu University of Traditional Chinese Medicine(成都中医药大学), 2015.
[29] LI C, RAO T, CHEN X, et al.HLA-B*35:01 allele is a potential biomarker for predicting Polygonum multiflorum-induced liver injury in humans[J]. Hepatology, 2019, 70(1): 346-357.
[30] HE LZ, YIN P, MENG YK, et al.Immunological synergistic mechanisms of trans-/cis-stilbene glycosides in Heshouwu-related idiosyncratic liver injury[J]. Science Bulletin, 2017, 62(11): 748-751.
[31] PANIS B, WONG DR, HOOYMANS PM, et al.Recurrent toxic hepatitis in a caucasian girl related to the use of Shou-Wu-Pian, a Chinese herbal preparation[J]. Journal of Pediatric Gastroenterology and Nutrition, 2005, 41(2): 256-258.
[32] HU XQ, LI M, YANG HL, et al.Effects of different ratios of tannin and stilbene glucoside from Polygonum multiflorum on liver biochemical indexes in rats[J]. Shanghai Journal of Traditional Chinese Medicine(上海中医药杂志), 2011, 45(4): 56-59.
[33] LI C, SU X, FENG WH, et al.Simultaneous determination of 12 mycotoxins in polygoni multiflori radix by UPLC-ESI-MS/MS combined with modified QuEChERS[J]. Chinese Pharmaceutical Journal(中国药学杂志), 2016, 41(23): 4368-4374.
[34] GUO LM, DUAN Q, LIU T.Determination of aflatoxin B1, B2, G1 and G2 in radix polygoni multiflori by HPLC[J]. Gansu Medical Journal(甘肃医药), 2015, 34(8): 618-621.
[35] ZHOU YJ, TANG JF, GAO F, et al.Determination of main chemical constituents in polygoni multiflori radix after nine steamings and nine sun-dryings and their effect on rat liver[J]. Central South Pharmacy, 2020, 18(4): 543-548.
[36] WANG YS, ZHU GY, WANG B, et al.Influences of ancient processing method steaming with black bean and drying and pharmacopoeia processing method continuous steaming with black bean decoction on 12 components of polygoni multiflori radix[J]. Chinese Traditional and Herbal Drugs, 2020, 51(19): 4972-4982.
[37] LIU YL, GAO D, LI XF, et al.Preliminary study on hepatotoxic components in Polygoni Multiflori Radix based on different adjuvants processing for detoxification[J]. Chinese Traditional and Herbal Drugs, 2020, 51(2): 330-337.
[38] SONG HB, DU XX, GUO XX, et al.Safety and risk factor analysis on polygoni multiflori radix base on ancient traditional Chinese medicine literatures[J]. Chinese Journal of Chinese Materia Medica(中国中药杂志), 2015, 40(5): 985-988.
[39] YANG JB, LIU Y, WANG Q, et al.Characterization and identification of the chemical constituents of Polygonum multiflorum Thunb. by high-performance liquid chromatography coupled with ultraviolet detection and linear ion trap FT-ICR hybrid mass spectrometry[J]. Journal of Pharmaceutical and Biomedical Analysis, 2019, 172, 149-166.
[40] RAO T, LIU YT, ZENG XC, et al.The hepatotoxicity of Polygonum multiflorum: the emerging role of the immune-mediated liver injury[J]. Acta Pharmacologica Sinica, 2020, 42(1): 1-9.
[41] ZHANG F, DENG Y, JIN XL, et al.Strengthening the teaching of biomarkers for pharmaceutical undergraduate[J]. Chinese Journal of Hospital Pharmacy, 2020, 40(5): 586-589.