中国药物警戒 ›› 2020, Vol. 17 ›› Issue (10): 707-709.
DOI: 10.19803/j.1672-8629.2020.10.12

• 安全与合理用药 • 上一篇    下一篇

注射用甘露聚糖肽致速发型过敏性休克严重不良反应分析

曹原1, 王雪1, 孙甜甜2, 高婕1,*   

  1. 1淄博市中心医院药学部,山东 淄博255036;
    2淄博市中心医院肿瘤科,山东 淄博255036
  • 收稿日期:2020-10-14 修回日期:2020-10-14 出版日期:2020-10-15 发布日期:2020-10-13
  • 通讯作者: *高婕,女,本科,主管药师,静脉用药医嘱审核和药事管理。E-mail: 18678187876@163.com
  • 作者简介:曹原,女,硕士,主管药师,临床药学。
  • 基金资助:
    淄博市重点研发计划（2018kj010091）

Severe Adverse Drug Reaction of Acute Anaphylactic Shock Induced by Mannatide

CAO Yuan1, WANG Xue1, SUN Tiantian2, GAO Jie1,*   

  1. 1Department of Pharmacy, Zibo Central Hospital, Zibo Shandong 255036, China;
    2Department of Oncology, Zibo Central Hospital, Zibo Shandong 255036, China
  • Received:2020-10-14 Revised:2020-10-14 Online:2020-10-15 Published:2020-10-13

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摘要： 目的 探索甘露聚糖肽致速发型过敏性休克严重不良反应的处理方法和经验。方法 甘露聚糖肽常用于治疗免疫功能低下导致的各种疾病,对2例使用该药物致速发型过敏性休克严重不良反应的实例进行分析。结果 2位患者均在滴注注射用甘露聚糖肽约10 min内发生过敏性休克不良反应。停用甘露聚糖肽、使用抗过敏药物、吸氧等对症治疗后,患者症状缓解。结论 临床使用甘露聚糖肽时,应在用药前仔细询问患者过敏史和病史,用药期间对患者进行严密监护。皮肤试验和给药前使用抗过敏药物可对不良反应的发生进行预防。

关键词: 甘露聚糖肽, 过敏, 不良反应, 皮试

Abstract: Objective To explore the methods of managing severe adverse drug reactions of acute anaphylactic shock induced by mannatide. Methods Two cases of severe adverse drug reactions of acute anaphylactic shock induced by mannatide, a drug often used for diseases caused by hypoimmunity, were analyzed. Results Both patients suffered from anaphylactic shock within about 10 minutes of intravenous drip of mannatide. The patients' symptoms were ameliorated after such symptomatic treatments as the withdrawal of mannatide, use of anti-allergic drugs and oxygen inhalation. Conclusion Clinicians are to learn about the allergic history and medical history of patients before the medication with mannatide injection. Patients should be closely monitored during medication. The skin test and use of anti-allergic drugs before administration could help prevent adverse drug reactions.

Key words: mannatide, allergy, adverse drug reaction, skin test

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