关键词: 腹腔脓肿, 克罗恩病, 沙利度胺, 临床药师, 亚胺培南西司他丁钠

Abstract: Objective To offer new ideas about the assessment, management and treatment of adverse drug reactions during clinical treatment by analyzing the medication adjustment of one case of Crohn's disease with peritoneal abscess. Methods The patient developed acute inflammatory demyelinating radiculopathy when taking thalidomide to combat Crohn's disease. When imipenem and cilastatin sodium for injection was used to treat abdominal abscess, urticaria appeared. Clinical pharmacists participated in the whole process of treatment and adjusted the dosage and frequency of thalidomide and antimicrobials. At the same time, the patient's conditions were monitored, including stool relief, temperature and abdominal abscess control, numbness of hands and feet, lisp aggravation and subsidence of urticaria. Results Physicians took the advice of clinical pharmacists, and monitored the patient's above conditions closely. The patient was basically recovered after 7 days in that his body temperature returned to normal, diarrhea became much less frequent, no pus outflowed from the fistula, and numbness of hands and feet as well as lisp stopped aggravating. Conclusion During clinical treatment, clinical pharmacists should actively collaborate with physicians in monitoring and treatment of adverse drug reactions, take effective interventions, and offer proper medication recommendations so as to work together to promote rational drug use and improve the therapeutic effect.

Key words: abdominal abscess, crohn's disease, thalidomide, clinical pharmacists, imipenem and cilastatin sodium