中国药物警戒 ›› 2020, Vol. 17 ›› Issue (9): 574-577.
DOI: 10.19803/j.1672-8629.2020.09.07

• 安全与合理用药 • 上一篇    下一篇

45例药源性高尿酸血症文献分析

徐菀佚, 崔向丽*   

  1. 首都医科大学附属北京友谊医院药学部,北京 100050
  • 收稿日期:2020-08-17 修回日期:2020-08-17 出版日期:2020-09-15 发布日期:2020-08-17
  • 通讯作者: *崔向丽,女,博士,主任药师。E-mail:cui10@163.com
  • 作者简介:徐菀佚,女,硕士,药师。
  • 基金资助:
    国家卫生健康委员会卫生技术评估重点实验室开放基金(FHTA2019-02):临床药师参与肺栓塞华法林抗凝治疗管理的成效与经济学评价

Literature Analysis of 45 Cases of Drug-induced Hyperuricemia

XU Wanyi, CUI Xiangli*   

  1. Department of Pharmacy, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China
  • Received:2020-08-17 Revised:2020-08-17 Online:2020-09-15 Published:2020-08-17

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摘要： 目的 分析汇总引起高尿酸血症的药物种类及临床特点,为临床安全用药和进行相关治疗提供参考。方法 通过检索中国知网、万方数据从建库至2019年8月31日药物引起高尿酸血症的个案报道相关文献,分析易引起高尿酸血症的药物及高风险因素。结果 共筛选出个案报道39篇,45例患者。共涉及7类(14种)药品,其中,占前2位的是利尿剂13例(28.89%),抗结核药12例(26.67%)。各个年龄组都有发生,60岁以上老年组比例最高(19例,42.22 %)。32例诱发痛风症状,13例为无症状高尿酸血症。结论 服用上述药物的患者,尤其是老年合并多种慢性疾病,需要长期、联合多种药物治疗时,应警惕药物导致的高尿酸血症,定期监测血尿酸水平,预防和避免高尿酸血症的发生。

关键词: 药源性, 高尿酸血症, 痛风, 文献分析

Abstract: Objective To investigate the types of drugs that cause hyperuricemia and the clinical features so as to provide reference for safe medication and treatment. Methods The CNKI and Wanfang database were searched to retrieve case reports of drug-induced hyperuricemia. The types of drugs responsible and high-risk factors were analyzed. Results A total of 39 case reports involving 45 patients were retrieved. A total of 7 categories (14 kinds) of drugs were involved, including 13 cases related to diuretics (28.89%) and 12 cases related to anti-tuberculosis drugs (26.67%). Hyperuricemia occurred in each age group, with those over 60 years old as the most vulnerable (19 cases, 42.22%). Gout occurred in 32 cases while asymptomatic hyperuricemia occurred in 13 cases. Conclusion Patients taking these drugs, especially the elderly with multiple chronic diseases who have to take long-term and combined multiple drugs, should be alert to drug-induced hyperuricemia, and the blood uric acid level should be monitored regularly to prevent the occurrence of hyperuricemia.

Key words: drug-induced, hyperuricaemia, gout, literature analysis

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