中国药物警戒 ›› 2019, Vol. 16 ›› Issue (8): 487-491.

• 安全性评价与合理用药 • 上一篇    下一篇

141例辛伐他汀不良反应文献分析

张晅, 顾云霞*   

  1. 江苏省苏北人民医院药学部,江苏 扬州225001
  • 收稿日期:2019-09-09 修回日期:2019-09-09 出版日期:2019-08-20 发布日期:2019-09-09
  • 通讯作者: *顾云霞,女,本科,副主任药师,临床药学。E-mail：gyx_716@163.com
  • 作者简介:张晅,女,硕士,主管药师,临床药学。
  • 基金资助:
    江苏省苏北人民医院资助项目（yzucms201633）：促进牙槽骨缺损修复的辛伐他汀溶致液晶的制备及其药效学初步研究

Literature Review of 141 Cases of Adverse Drug Reactions Induced by Simvastatin

ZHANG Xuan, GU Yunxia*   

  1. Northern Jiangsu People's Hospital, Jiangsu Yangzhou 225001, China
  • Received:2019-09-09 Revised:2019-09-09 Online:2019-08-20 Published:2019-09-09

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摘要： 目的 研究辛伐他汀致不良反应的特征,为临床安全用药提供参考。方法 以“辛伐他汀”和“不良反应”为检索词,检索中国期刊网全文数据库、万方数据资源、维普中文科技期刊全文数据库,按纳入与排除标准对文献资料进行统计和分析。结果 共纳入123篇文献,提取病例141例。不良反应损害以肌肉骨骼系统和肝胆系统为主,多发生在用药的90 d内。结论 关注辛伐他汀不良反应,加强临床合理用药指导,确保用药安全。

关键词: 辛伐他汀, 不良反应, 文献分析

Abstract: Objective To provide references for the safe and rational use of simvastatin in clinic through investigating the characteristics of adverse drug reactions (ADRs) induced by this drug. Methods Using "simvastatin", "adverse reaction" as key words to search and retrieve articles in the CNKI database, WanFang database and VIP Chiese full-text database. The literature was analyzed according to the inclusion and exclusion criteria. Results A total of 123 papers, 141 cases were included. Systems and organs mainly involved in ADRs were musculo-skeletal system disorders and liver and biliary system disorders. ADRs occurred most frequently within 90 days of medication. Conclusion It is important for clinicians and patients to make aware of simvastatin-induced ADRs. Supervision and precaution should be strengthened in the clinical use of simivastatin.

Key words: simvastatin, adverse drug reactions, literature review

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