中国药物警戒 ›› 2011, Vol. 8 ›› Issue (8): 492-494.

• 综述 • 上一篇    下一篇

基于分子水平的AD治疗药物作用机制研究进展

钱晓路1, 2, 孙蓉1, *   

  1. 1 山东省中医药研究院,山东 济南 250014;
    2 山东中医药大学,山东 济南 250355
  • 收稿日期:2011-03-07 出版日期:2011-08-10 发布日期:2015-07-30
  • 通讯作者: 孙蓉,女,研究员,硕士生导师,中药药理与毒理研究。 E-mail:sunrong107@163.com
  • 作者简介:钱晓路,男,在读硕士研究生,中药药理与毒理。
  • 基金资助:
    中药复方药理学研究及药效学评价关键技术（2009ZX09502-015）; 山东省重大新药创制综合性大平台中药单元平台中药药理与毒理子平台建设（2009ZX09301-013）

The Study of Drug Treatment of Alzheimer's Disease Related with Molecular Mechanisms

QIAN Xiao-lu1, 2, SUN Rong1, *   

  1. 1 Shandong Research Academy of TCM, Shandong Jinan 250014, China;
    2 Shandong University of Traditional Chinese Medicine, Shandong Jinan 250355, China
  • Received:2011-03-07 Online:2011-08-10 Published:2015-07-30

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摘要： 目的 通过总结Alzheimer's disease（AD）的致病机制,探讨目前临床上抗AD药物的研究进展情况,为临床合理用药及相关创新药物的研发提供参考和思路。方法 通过查阅国内外相关文献,整理、分析、归纳AD的最新研究进展和药物治疗情况。结果 AD由于病因、致病机制复杂,导致其致病机制假说众多,目前市场上的治疗药物大多是针对单一致病机制而研制的,没有考虑到疾病不同时间、阶段、个体差异等因素对治疗药物的要求,导致了大多数药物在AD治疗时具有一定的局限性,并且由于某些药物的毒副作用,这就给临床合理用药带来了诸多困难。结论 中药由于其在AD治疗上表现出的独特的治疗效果,受到越来越多学者的重视,其中中药单体成分在AD治疗方面的研究已经较为完善,但是中药复方、复方多成分之间相互作用及对分子机制相关性影响的研究还较少,因此我们应加强药物多成分之间药效及机制相关性的研究,为更好地、有效地、快捷地开发创新药物提供文献依据。

关键词: 阿尔茨海默病, 致病机制, 药物治疗

Abstract: Objective The drug treatment of Alzheimer's Disease(AD) was studied by summarizing the pathogenesis of AD, in order to provide reference and ideas for clinical rational drug use and the development of AD innovative drugs. Methods The related references in recent years both at home and abroad about the latest achievements of AD and the drug treatment were analyzed, collated and summarized. Results The causes of AD were complex, so there were many hypothesis of the pathogenesis about AD, now many of AD drugs are developed for single mechanism that can't consider of the different factors in Alzheimer' Disease and many of them have side effects, so this brings difficulties for clinical rational drug use. Conclusion The scholars have paid more attention to traditional Chinese medicine(TCM), because its unique treatment to AD. But it usually focused on the single composition, the compound of TCM、the multi-component studies have little advancements, so we must do more researches in this respect, in order to provide references and research ideas for innovative drugs.

Key words: Alzheimer' Disease, pathogenic mechanisms, drug treatment

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