92例利培酮片不良反应报告分析

doi:10.19803/j.1672-8629.2022.05.17

摘要/Abstract

摘要： 目的分析利培酮片致不良反应的发生特点,为该药的临床安全应用提供参考。方法对2015年1月1日到2019年12月31日新疆生产建设兵团不良反应监测中心收到的92例利培酮片不良反应报告进行分析。结果女性患者数量是男性的2.29倍;以18~44岁的患者居多（68.48%）;累及系统主要为中枢及外周神经系统（51.02%）、心脏（16.33%）、胃肠系统（9.18%）,临床表现为锥体外系病、心动过速、窦性心动过缓、月经紊乱、肝功能异常等。结论临床应警惕利培酮片引起的不良反应,关注女性患者用药安全;加强上报人员培训,提高报告质量。

关键词: 利培酮片, 药品不良反应, 分析

Abstract: Objective To analyze the characteristics of adverse drug reactions (ADR) of risperidone tablets so as to provide reference for rational drug use. Methods Ninety-two cases of ADR caused by risperidone tablets that were collected by Xinjiang Production and Construction Corps Center for ADR Monitoring were from January 1, 2015 to December 31, 2019 analyzed. Results There were 2.29 times as many female patients as male ones. Most of the patients ranged from 18 to 44 years old (68.48%). ADR included central and peripheral nervous system diseases (51.02%), heart diseases(16.33%), gastrointestinal diseases (9.18%). Clinical manifestations included extrapyramidal disorders, tachycardia, sinus bradycardia, menstrual disorders, and abnormal liver function. Conclusion Clinicians should be alert to ADR caused by risperidone tablets in clinical practice, care for medication safety of female patients, and strengthen the training of reporting personnel so as to improve the quality of reports.

Key words: risperidone tablets, adverse drug reaction, analysis, extrapyramidal disorders

中图分类号:

R969
R994.11

蒋艳琼, 刘红建, 刘晓霞. 92例利培酮片不良反应报告分析[J]. 中国药物警戒, 2022, 19(5): 554-556.

JIANG Yanqiong, LIU Hongjian, LIU Xiaoxia. 92 cases of adverse drug reactions induced by risperidone tablets[J]. Chinese Journal of Pharmacovigilance, 2022, 19(5): 554-556.

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