中国药物警戒 ›› 2014, Vol. 11 ›› Issue (6): 355-357.

• 药械安全性研究 • 上一篇    下一篇

109例头孢哌酮钠舒巴坦钠不良反应报告分析

刘宪军1, 付娜2   

  1. 1首都医科大学潞河教学医院,北京 101149;
    2北京市药品不良反应监测中心,北京 100024
  • 收稿日期:2013-11-19 修回日期:2016-02-03 出版日期:2014-06-08 发布日期:2016-03-02
  • 作者简介:刘宪军,男,硕士,副主任药师,临床药学。

Analysis of 109 Reports of Adverse Drug Reaction of Cefoperazone Sodium and Sulbactam Sodium for Injection

LIU Xian-jun1FU Na2   

  • Received:2013-11-19 Revised:2016-02-03 Online:2014-06-08 Published:2016-03-02

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摘要： 目的探讨头孢哌酮钠舒巴坦钠致不良反应发生的相关因素,为临床安全合理用药提供参考。方法采用回顾性研究方法,对2012年1月~2012年10月北京市药品不良反应监测中心收集的109例注射用头孢哌酮钠舒巴坦钠不良反应报告进行统计分析。结果头孢哌酮钠舒巴坦钠致不良反应累及系统-器官主要为皮肤及其附件、血液系统、胃肠系统、肝胆系统及全身性损害。多数不良反应出现在用药后30 min内,且以联合用药出现不良反应的症状较重。结论头孢哌酮钠舒巴坦钠致不良反应与其化学结构、患者个体体质、饮食、联合用药等有关。加强注射用头孢哌酮钠舒巴坦钠的合理使用及用药监护,可以避免或减少不良反应的发生。

关键词: 头孢哌酮钠舒巴坦钠, 药品不良反应, 合理用药

Abstract: Objective To investigate relevant factors of the adverse drug reaction induced by cefoperazone sodium and sulbactam sodium for injection to provide scientific reference for the safe and rational drug use in clinic. Methods 109 ADR reports of cefoperazone sodium and sulbactam sodium for injection collected by Beijing Center for ADR Monitoring from January 2010 to October 2010 were statistically analyzed retrospectively. Results The clinical manifestations of ADR involved skins and appendages damage, blood system damage, digestive system damage, hepatobiliary system damage and generalized lesion． Most ADR cases occurred in 30 minutes after medication, and drug combination maybe cause serious adverse reactions． Conclusion The ADR induced by cefoperazone sodium and sulbactam sodium for injection is associated with its chemical structure, individual diathesis, different diet, drug combination and so on. In order to avoid the occurrence of ADR induced by cefoporazone sodium and sulbactam sodium for injection, the drug must be used rationally and the patient should be intensively warded.

Key words: cefoporazone sodium and sulbactam sodium, adverse drug reaction, rational drug use

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