中国药物警戒 ›› 2010, Vol. 7 ›› Issue (10): 577-578.

• 基础及临床研究 •    下一篇

续断通络片对糖尿病大鼠坐骨神经传导速度影响的实验研究

杨晓晖,邓媛媛   

  1. 北京中医药大学东方医院,北京 100078
  • 收稿日期:2010-08-06 修回日期:2016-03-12 出版日期:2010-10-08 发布日期:2016-03-09
  • 作者简介:杨晓晖,男,医学博士,主任医师,博士研究生导师,糖尿病及其并发症的临床与实验研究、药物临床评价。

The Impact of Xu Duan Tong Luo Pian on Nerve Conduction Velocity of Experimental Diabetic Rats

YANG Xiao-hui ,DENG Yuan-yuan   

  1. Dongfang Hospital Affiliated to Beijing University of Chinese Medicine, Beijing 100078, China
  • Received:2010-08-06 Revised:2016-03-12 Online:2010-10-08 Published:2016-03-09

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摘要： 目的 观察中药复方制剂续断通络片对糖尿病大鼠神经传导速度的影响。方法 采用链脲佐菌素（STZ）诱导的糖尿病大鼠模型,随机分为模型组、甲钴胺组、续断通络片低剂量组、续断通络片中剂量组和续断通络片高剂量组,给予续断通络片（生药）灌胃,以甲钴胺作为对照,疗程8 周,分别于给药的2、4、6、8 周检测大鼠的坐骨神经传导速度。结果 经续断通络片中、高剂量治疗的DM大鼠在造模8周后血糖明显下降（ P<0.05）,在4、6、8周均可明显改善神经传导速度（P <0.05 或P<0.01）,低剂量续断通络片治疗组在6 周时可明显改善神经传导速度（P <0.05）,余无明显差异。结论 续断通络片能够改善STZ-DM 大鼠的神经传导速度,各个剂量及各个时间均有较为明显的改善,显示续断通络片对糖尿病大鼠周围神经病变有明显改善作用。

关键词: 续断通络片, 糖尿病周围神经病变, 实验研究

Abstract: Objective To observe the impact of Xu Duan Tong Luo Pian(XDTLP) on nerve conduction velocity(NCV) of experimental diabetic peripheral neuropathy(DPN) rats. Methods Diabetic rats were induced by STZ celiac injection. Then, the rats which successfully became diabetic model were divided into diabetic model group. Methycobal was given by 0.25mg/kg·d, XDTLP was given by3.2、6.3、12.6g/kg·d herb according to low, middle and high dose, which lasted 8 weeks. Results After treatment with XDTLP for8 weeks, NCV increased greatly. Conclusion The experiment showed that XDTLP can significantly improve the nerve conductive velocity in rats with DPN.

Key words: Xu Duan Tong Luo Pian, diabetic peripheral neuropathy, experimental research

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