地佐辛注射液致人类免疫缺陷病毒感染患者成瘾1例分析

doi:10.19803/j.1672-8629.20230048

中国药物警戒 ›› 2023, Vol. 20 ›› Issue (10): 1181-1183.
DOI: 10.19803/j.1672-8629.20230048

地佐辛注射液致人类免疫缺陷病毒感染患者成瘾1例分析

沈倩, 张蕾^*

南京医科大学附属江苏盛泽医院药学部,江苏苏州 215228

收稿日期:2023-02-03 出版日期:2023-10-15 发布日期:2023-10-16
通讯作者: ^*张蕾,女,硕士,副主任药师,临床药学。E-mail：353328766@qq.com
作者简介:沈倩,女,本科,主管药师,临床药学。
基金资助:
2022年度“苏州市药学会-常州四药临床药学科研基金”研究项目（SKYXD2022011）; 苏州市吴江区“科教兴卫”项目（wwk201814）

One case of addiction induced by dezocine injection in a patient with HIV

SHEN Qian, ZHANG Lei^*

Department of Pharmacy, Jiangsu Shengze Hospital Affiliated to Nanjing Medical University, Suzhou Jiangsu 215228, China

Received:2023-02-03 Online:2023-10-15 Published:2023-10-16

摘要/Abstract

摘要： 目的探讨地佐辛注射液致人类免疫缺陷病毒感染患者成瘾不良反应及其影响因素分析,为临床上安全用药提供参考。方法结合文献分析本院1例人类免疫缺陷病毒感染患者地佐辛注射液成瘾机制和影响因素。结果地佐辛注射液成瘾机制与对μ受体有部分激动、抑制5-羟色胺重吸收和去甲肾上腺素再摄取、κ受体激动相关。本例患者连续使用地佐辛注射液40余天,用药疗程过长,剂量过大可使地佐辛成瘾的风险显著增加。结论临床应用地佐辛注射液应严格把握适应证,防止滥用,避免长期使用。

关键词: 地佐辛, 药物依赖性, 镇痛治疗, 人类免疫缺陷病毒, 成瘾

Abstract: Objective To explore the adverse reactions to addiction caused by dezocine injection in an HIV patient and analyze the influencing factors so as to provide reference for clinical safety. Methods The clinical data of an HIV patient with dezocine injection addiction treated in our hospital was analyzed while the mechanism and influencing factors of dezocine injection addiction were discussed based on literature review. Results The mechanism of addiction to dezocine injection was related to partial activation of μ receptors, inhibition of serotonin reabsorption and norepinephrine reuptake, and κ receptor activation. This patient had been using dizocine injection for more than forty consecutive days. Too long a course of treatment and too high a dose could significantly increase the risk of addiction to dezocine. Conclusion In clinical application of dezocine injection, the indications should be strictly controlled to prevent abuse and avoid long-term use.

Key words: dezocine, drug dependence, analgesic therapy, HIV, addiction

中图分类号:

R971
R994

沈倩, 张蕾. 地佐辛注射液致人类免疫缺陷病毒感染患者成瘾1例分析[J]. 中国药物警戒, 2023, 20(10): 1181-1183.

SHEN Qian, ZHANG Lei. One case of addiction induced by dezocine injection in a patient with HIV[J]. Chinese Journal of Pharmacovigilance, 2023, 20(10): 1181-1183.

参考文献

[1] WANG YH, CHAI JR, XU XJ, et al.Pharmacological characterization of dezocine, a potent analgesic acting as a κ partial agonist and μ partial agonist[J]. Sci Rep, 2018, 8(1): 14087.
[2] LIU R, HUANG XP, YELISEEV A, et al.Novel molecular targets of dezocine and their clinical implications[J]. Anesthesiology, 2014, 120(3): 714-723.
[3] WHO Expert Committee on Drug Dependence. Twenty-sixth report[J]. World Health Organ Tech Rep Ser, 1989, 787: 1-32.
[4] ZHU H, SHAO JP, LIAN HB, et al.A case of dependence caused by dezocine injection[J]. Pharmaceutical and Clinical Research(药学与临床研究), 2014, 22(3): 285.
[5] ZHAO RJ, NIU YJ, YANG KB, et al.A case of dezocine injection dependence[J]. Chinese Journal of Psychiatry(中华精神科杂志), 2015, 48(5): 319-320.
[6] QUAN LX, ZHOU W, LIU FL.A case of dezocine injection dependence[J]. Chinese Journal of Drug Dependence(中国药物依赖性杂志), 2017, 26(6): 483-484.
[7] YANG F, LIU W, HAO W.A case of comorbidity depression due to dezocine injection dependence[J]. Chinese Journal of Drug Dependence(中国药物依赖性杂志), 2019, 28(2): 153-156.
[8] ZHANG XB.A case of addiction to repeated intravenous injection of dezocine injection[J]. Chinese Journal of Drug Dependence(中国药物依赖性杂志), 2019, 28(2): 157-158.
[9] CHEN JF, YANG JH.Analysis based on a typical case of drug dependence caused by dezocine injection[J]. Chinese Journal of Drug Dependence(中国药物依赖性杂志), 2019, 28(6): 478-480.
[10] WANG X, LIU SS, WANG C, et al.Analysis of dependence of dezocine injection in 1 case[J]. Chinese Journal of Drug Dependence(中国药物依赖性杂志), 2023, 32(1): 84-86.
[11] XU TT, CAI J, HU LQ, et al.A case analysis of drug dependence caused by dezocine injection[J]. Chinese Journal of Drug Dependence(中国药物依赖性杂志), 2023, 32(1): 80-83.
[12] NARANJO CA, BUSTO U, SELLERS EM, et al.A method for estimating the probability of adverse drug reactions[J]. Clin Pharmacol Ther, 1981, 30(2): 239-245.
[13] National Adverse Drug Reaction Monitoring Center. Training materials on Adverse drug reaction reporting and monitoring management(药品不良反应报告和监测管理办法培训教材) [M]. Beijing: China Medical Sciences Press, 2012.
[14] CHEN C, SHI SJ, HU YK, et al Investigation on the clinical use of dezocine injection in 12847 patients in a hospital[J]. Chinese Pharmacist(中国药师), 2017, 20(9): 1601-1603.
[15] ZHANG RM, ZHANG RL, ZHAO M, et al.Guidelines for the diagnosis and treatment of opioid use related disorders (III)[J]. Chinese Journal of Drug Abuse Prevention and Control(中国药物滥用防治杂志), 2017, 23(3): 129-131,138.
[16] ZHANG H, SHI YG, WOODS JH, et al.Central kappa-opioid receptor-mediated antidepressant-like effects of nor-Binaltorphimine: behavioral and BDNF mRNA expression studies[J]. Eur J Pharmacol, 2007, 570(1-3): 89-96.
[17] ZHANG XB.The risk of addiction and its prevention and treatment in pain treatment with dezocine[J]. Chinese Journal of Drug Dependence(中国药物依赖性杂志), 2020, 29(1): 73-77.
[18] CHEN XQ, JIN YY, TANG G. New Pharmacology (新编药物学) [M]. 18th Edition, Beijing: People's Medical Publishing House, 2018.
[19] YANG KJ, ZHOU YC, QI ST.The formation mechanism of psychological addiction to opioids[J]. Chinese Journal of Microinvasive Neurosurgery(中国微侵袭神经外科杂志), 2005, 10(2): 91-94.
[20] CHOU R, GORDON DB, DE LEON-CASASOLA OA, et al. Management of postoperative pain: a clinical practice guideline from the American Pain society, the American Society of Regional Anesthesia and Pain Medicine, and the American Society of Anesthesiologists' Committee on Regional Anesthesia, Executive Committee, and Administrative Council[J]. J Pain, 2016, 17(2): 131-157.
[21] Chinese Society of Anesthesiology. Expert consensus on post-operative pain management in adults[J]. Journal of Clinical Anesthesiology(临床麻醉学杂志), 2017, 33(9): 911-917.

地佐辛注射液致人类免疫缺陷病毒感染患者成瘾1例分析

One case of addiction induced by dezocine injection in a patient with HIV

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 4

编辑推荐

Metrics

[1]	唐炯, 刘颖. 依非韦伦致男性乳房发育1例分析[J]. 中国药物警戒, 2023, 20(11): 1306-1308.
[2]	周博雅, 袁偲偲, 冯欣. 哺乳期女性服用洛匹那韦/利托那韦对乳儿影响的研究进展[J]. 中国药物警戒, 2022, 19(3): 296-301.
[3]	何艳, 张锦文. 地佐辛注射液致静脉血栓1例分析[J]. 中国药物警戒, 2021, 18(8): 793-794.
[4]	孙祯辉, 孙骏, 王佳域, 于丹丹, 王玲, 余正. 曲马多复方制剂监管现状研究[J]. 中国药物警戒, 2019, 16(9): 528-535.