中国药物警戒 ›› 2022, Vol. 19 ›› Issue (4): 349-352.
DOI: 10.19803/j.1672-8629.2022.04.01

• 毒性中草药研究与利用专栏 • 上一篇    下一篇

基于本草古籍的中药毒性分级及影响因素探讨

付璐1,2, 金艳1, 彭华胜1, 袁媛1,*   

  1. 1中国中医科学院中药资源中心,北京 100700;
    2中国中医科学院博士后科研流动站,北京 100700
  • 收稿日期:2021-10-30 发布日期:2022-04-15
  • 通讯作者: *袁媛,女,博士,研究员,中药鉴定与分子生药学。E-mail:y_yuan0732@163.com
  • 作者简介:付璐,女,博士后,中外医学交流及本草考古。
  • 基金资助:
    国家重点研发计划（2020YFE0205100）; 国家科技基础资源调查专项（2018FY100800）; 中央本部级重大支减项目（2060302）; 中央级公益性科研院所基本科研业务费专项资金资助（ZZ10-008）; 中国中医科学院中药资源中心自主选题（zzxt202107）

Classification and influencing factors of toxicity of Chinese medicine based on ancient books of materia medica

FU Lu1,2, JIN Yan1, PENG Huasheng1, YUAN Yuan1,*   

  1. 1National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Science, Beijing 100700, China;
    2Postdoctoral Research Station of China Academy of Chinese Medical Science, Beijing 100700, China
  • Received:2021-10-30 Published:2022-04-15

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摘要： 目的 基于本草古籍毒性分类对现有中药毒性分级方法提出改进意见。方法 采用文献学研究方法梳理历代本草古籍对中药毒性的论述,厘清中药毒性概念的起源、中药毒性分级的演变过程以及影响中药毒性的主要因素。结果 历代中药毒性的分级经历了三品分类、四级分类、五级分类法,不同的基原、炮制、服法及患者体质的差异皆会影响药物的毒性。结论 应从药材性质、临床应用两个维度,构建一个多层级、多因素的中药毒性评价体系。药材性质包括药物的基原植物、药用部位、炮制方法的细化,临床应用包括给药方式、时间、剂量以及患者体质因素对药品不良反应的影响。

关键词: 中药毒性, 中药毒性分级, 本草古籍

Abstract: Objective To propose ways of improving the current methods of toxicity classification of traditional Chinese medicine (TCM) based on the review of ancient records of toxicity of Chinese herbal medicines. Methods The literature research method was used to search for literature related to the toxicity of TCM in ancient Chinese herbal books and to clarify concepts of TCM toxicity, the evolution of toxicity classification of TCM, and the main determinants of the toxicity of TCM. Results The classification of the toxicity of TCM has undergone three-level classification, four-level classification, and five-level classification. The difference in genes, preparations, medications, and physique of patents will affect the toxicity of TCM. Conclusion A multi-level and multi-factor toxicity evaluation system for TCM should be established, involving the source of the medicine, methods of preparation, the time and dosage of the medicine used, and the condition of the patient.

Key words: toxicity of Chinese materia medica, toxicity classification of Chinese materia medica, ancient books of materia medica

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