中国药物警戒 ›› 2022, Vol. 19 ›› Issue (4): 369-371.
DOI: 10.19803/j.1672-8629.2022.04.05

• 毒性中草药研究与利用专栏 • 上一篇    下一篇

基于本草古籍的花椒毒性考证

付璐1,2, 彭华胜1, 袁媛1, 金艳1,*   

  1. 1中国中医科学院中药资源中心,北京 100700;
    2中国中医科学院博士后科研流动站,北京 100700
  • 收稿日期:2021-11-01 发布日期:2022-04-15
  • 通讯作者: *金艳,女,副研究员,中药鉴定。E-mail：jy20047@163.com
  • 作者简介:付璐,女,博士后,中外医学交流及本草考古。
  • 基金资助:
    国家重点研发计划（2020YFE0205100）; 国家科技基础资源调查专项（2018FY100800）; 中央本部级重大支减项目（2060302）; 中央级公益性科研院所基本科研业务费专项资金资助（ZZ10-008）; 中国中医科学院中药资源中心自主选题（zzxt202107）

Herbal textual research on toxicity of Zanthoxylum bungeanum

FU Lu1,2, PENG Huasheng1, YUAN Yuan1, JIN Yan1,*   

  1. 1National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China;
    2Postdoctoral Research Station of China Academy of Chinese Medical Sciences, Beijing 100700, China
  • Received:2021-11-01 Published:2022-04-15

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摘要： 目的 基于本草古籍对花椒进行毒性考证,从品种、产地、药性、炮制等角度探寻对花椒毒性的影响,为现代花椒的临床应用提供文献依据。方法 基于历代本草古籍梳理花椒的毒性记载,探寻花椒毒性的相关因素。结果 古籍所载花椒可分为药用花椒与食用花椒2类,蜀椒、秦椒等药用花椒品种的毒性高于食用花椒。花椒属火、性热、气味辛烈,久食、多食会引起邪火上炎,导致气喘、牙痛、目昏等不良反应。通过加热、捡净、与他药同制等方法炮制,可在一定程度上减低花椒的毒性。结论 花椒的毒性与品种、产地、炮制方法、服用方法及患者体质有一定相关性,临床使用时应注意使用方法及辨证施治。

关键词: 花椒, 本草考证, 中药毒性, 本草古籍

Abstract: Objective To study the toxicity of Zanthoxylum Bungeanum based on herbal literature and analyze the influence of origin, places of production, medicinal properties, and processing methods on the toxicity of Zanthoxylum bungeanum so as to contribute to the clinical application of Zanthoxylum bungeanum. Methods The herbal textual research method was used to sort out the ancient records of toxicity of Zanthoxylum bungeanum, and the related influencing factors were analyzed. Results Zanthoxylum bungeanum documented in ancient books could be divided into two categories: medicinal and edible. The varieties of Zanthoxylum bungeanum used as medicines were more toxic than those used as foods. Zanthoxylum bungeanum had hot medicinal properties and a pungent smell. Excessive use could cause such adverse reactions as asthma, toothache and clouded vision. The toxicity of Zanthoxylum bungeanum could be reduced by heating, cleaning, and preparing it with other herbs. Conclusion The toxicity of Zanthoxylum bungeanum is related to its origin, place of production, processing methods, ways of administration and patients' condition. Therefore, the clinical use of Zanthoxylum bungeanum involves using different methods and distinguishing the syndrome of patients.

Key words: Zanthoxylum bungeanum, herbal textual research, toxicity of Chinese materia medica, ancient books of maten medica

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