彝族药地胆草的研究进展及质量标志物的预测分析

doi:10.19803/j.1672-8629.20210311

摘要/Abstract

摘要： 彝族药地胆草是一味含有多种化学成分并具有清热凉血、解毒利湿作用的中药,近年来研究发现其具有广泛的药理作用,主要用于抗肿瘤、抗炎、抗病毒、保肝等方面。本文对地胆草中的倍半萜内酯类、黄酮类、三萜类等成分进行阐述以及分析,对药理作用进行综述,并在此基础上基于中药质量标志物（Q-marker）的概念,从植物亲缘学和化学成分特有性、传统功效等方面对地胆草Q-marker进行预测分析,推测地胆草中的倍半萜内酯类、黄酮类、三萜类等可作为质量标志物,为其质量评价提供一定参考。

关键词: 地胆草, 倍半萜内酯类, 黄酮类, 抗肿瘤, 抗炎, 质量标志物

Abstract: Elephantopus scaber L. is a traditional Chinese medicine which contains a variety of chemical components and has the functions of clearing heat, cooling blood, detoxification and diuresis. In recent years, studies have found that it has a wide range of pharmacological effects, such as anti-tumor, anti-inflammatory, anti-virus and liver-protecting properties. In this paper, flavonoids, steroids, triterpenoids and sesquiterpene lactones in Elephantopus scaber L. were described and analyzed, and the pharmacological effects were summarized. Based on the concept of quality markers (Q-markers) of traditional Chinese medicines, the Q-markers of Elephantopus scaber L. were predicted and analyzed in terms of pharmaphylogeny, component specificity and traditional efficacy. It was speculated that sesquiterpene lactones flavonoids and triterpenoids in Elephantopus scaber L. could be used as quality markers for quality evaluation.

Key words: Elephantopus scaber L., sesquiterpene lactones, flavonoids, antineoplastic, anti-inflammatory, Q-Marker

中图分类号:

R927.11

果佳慧, 蔡于罗, 甄亚钦, 王鑫国, 牛丽颖, 陈钟. 彝族药地胆草的研究进展及质量标志物的预测分析[J]. 中国药物警戒, 2022, 19(11): 1272-1276.

GUO Jiahui, CAI Yuluo, ZHEN Yaqin, WANG Xinguo, NIU Liying, CHEN Zhong. Research progress in Yi medicine Elephantopus scaber L. and predictive analysis of quality markers[J]. Chinese Journal of Pharmacovigilance, 2022, 19(11): 1272-1276.

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