中国药物警戒 ›› 2023, Vol. 20 ›› Issue (3): 348-352.
DOI: 10.19803/j.1672-8629.20210520

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彝族药蜘蛛香的研究进展及质量标志物的预测分析

蔡于罗1, 果佳慧1, 王鑫国1,2,3, 田义龙1,2,3, 王梦1,2,3, 牛丽颖1,2,3#, 李军山1,2,3,4,*   

  1. 1河北中医学院,河北 石家庄 050091;
    2河北省中药配方颗粒技术创新中心,河北 石家庄 050091;
    3河北省中药材品质评价与标准化工程研究中心,河北 石家庄 050091;
    4神威药业集团有限公司,河北 石家庄 051430
  • 收稿日期:2021-05-20 出版日期:2023-03-15 发布日期:2023-03-17
  • 通讯作者: * 李军山,男,本科,正高级工程师,药物工艺及质量标准。 E-mail: swljs@sina.com;#为共同通信作者。
  • 作者简介:蔡于罗,女,在读硕士,中药分析及药效物质基础。
  • 基金资助:
    中央引导地方科技发展资金项目(206Z2501G); 河北省重点研发计划(20372502D); 河北省自然科学基金资助项目(H2019423050)

Research progress in Yi medicine Valeriana jatamans and predictive analysis of related quality markers

CAI Yuluo1, GUO Jiahui1, Wang Xinguo1,2,3, TIAN Yilong1,2,3, WANG Meng1,2,3, NIU Liying1,2,3#, LI Junshan1,2,3,4,*   

  1. 1Hebei University of Chinese Medicine, Shijiazhuang Hebei 050091, China;
    2Hebei TCM Formula Granule Innovation Center, Shijiazhuang Hebei 050091, China;
    3Hebei TCM Quality Evaluation & Standardization Engineering Research Center, Shijiazhuang Hebei 050091, China;
    4Shineway Pharmaceutical Group Ltd., Shijiazhuang Hebei 051430, China
  • Received:2021-05-20 Online:2023-03-15 Published:2023-03-17

摘要: 彝族药蜘蛛香(Valeriana jatamansi Jones)中含有多种化学成分,主要为环烯醚萜类、挥发油类、木脂素类和黄酮类。据现代药学研究表明,蜘蛛香有多种药理作用,如中枢抑制作用、抗菌和抗病毒作用、细胞毒性和抗肿瘤作用等。本文基于中药质量标志物的概念,从蜘蛛香化学成分特有性、传统药效、传统药性、化学成分可测性等几个方面,对蜘蛛香的中药质量标志物成分进行预测分析,以期为蜘蛛香的质量控制和合理应用提供新思路。

关键词: 蜘蛛香, 环烯醚萜, 挥发油, 药理作用, 质量控制, 质量标志物

Abstract: The Yi medicine Valeriana jatamansi contains many chemical components, such as iridoids, volatile oils, lignans and flavonoids. According to modern pharmaceutical research, Valeriana jatamansi delivers a range of pharmacological effects, such as central inhibition, antibacterial and antiviral effects, cytotoxicity and anti-tumor effect. Based on the concept of Q-markers, this article predicted and analyzed the Q-marker components of Valeriana jatamansi in terms of specificity, traditional medicinal effects, traditional medicinal properties, and measurability of chemical constituents in the hopes of providing reference for quality control and rational use of Valeriana jatamansi.

Key words: Valeriana jatamansi, iridoids, volatile oils, pharmacological effects, quality control, quality marker

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