呼吸科抗菌药物不良反应报告分析和防范措施

doi:10.19803/j.1672-8629.2021.11.19

中国药物警戒 ›› 2021, Vol. 18 ›› Issue (11): 1083-1086.
DOI: 10.19803/j.1672-8629.2021.11.19

呼吸科抗菌药物不良反应报告分析和防范措施

韦元元^1,2,3, 栗芳^1,2,3, 陶小妹^1,2,3, 顾红燕^1,2,3,*

¹首都医科大学附属北京世纪坛医院药剂科,北京 100038;
²临床合理用药评价北京市重点实验室,北京 100038;
³临床合理用药评价国际合作联合实验室,北京 100038

收稿日期:2020-06-15 发布日期:2021-11-18
通讯作者: ^*顾红燕,女,副主任药师,临床药学。E-mail：ghyhappycpu@163.com
作者简介:韦元元,女,主管药师,临床药学。
基金资助:
北京市优秀人才“青年拔尖团队”项目(2018000021223TD09)

Prevention of Adverse Reactions of Antibiotics in a Respiratory Department

WEI Yuanyuan^1,2,3, LI Fang^1,2,3, TAO Xiaomei^1,2,3, GU Hongyan^1,2,3,*

¹Department of Pharmacy, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China;
²Beijing Key Laboratory of Bio-characteristic Profiling for Evaluation of Rational Drug Use, Beijing 100038, China;
³International Cooperation & Joint Laboratory of Bio-characteristic Profiling for Evaluation of Rational Drug Use, Beijing 100038, China

Received:2020-06-15 Published:2021-11-18

摘要/Abstract

摘要： 目的分析我院呼吸科抗菌药物的药品不良反应（ADR）报告并提出防范措施,促进抗菌药物的临床合理应用。方法采用回顾性研究方法,对2016年1月31日至2018年8月31日我院呼吸科抗菌药物ADR报告进行统计,分析ADR患者年龄、药物分布及ADR发生的时间分布和临床特征等,共纳入51例ADR报告,并重点分析3例严重ADR的特征。结果老年患者ADR发生较多。左氧氟沙星、哌拉西林他唑巴坦及伏立康唑ADR居前3位。ADR多发生在用药后1 d内。临床药师针对出现的问题提出防范措施。结论应加强重点药物和老年患者的药学监护,合理选择药物,保障患者用药安全。

关键词: 抗菌药物, 药品不良反应, 合理用药, 药学服务

Abstract: Objectiv eTo analyze the adverse drug reaction (ADR) that occur in a respiratory department and recommend precautions for the sake of rational use of antibiotics in clinic. Methods ADR reports of antibiotics in a hospital between January 31, 2016 and August 31, 2018 were retrospectively analyzed. The incidence of antibiotics-related ADR in different age groups, drug varieties, the time adverse reactions occurred, systems and organs involved and clinical manifestations were analyzed．A total of fifty-one ADR cases were included in this study. The characteristics of three cases of serious ADR were studied．ResultsElderly patients were more vulnerable to ADR in wards of a respiratory department. Levofloxacin, piperacillin-tazobactam and voriconazole were the top three drugs that were responsible for ADR. Most of the ADR were found within one day of treatment. Clinical pharmacists suggested precautions against ADR. Conclusion We should strengthen ADR monitoring of key drugs and elderly patients in order to ensure medication safety of patients by selecting the right drugs.

Key words: antibiotics, adverse drug reactions, rational administration, pharmaceutical care

中图分类号:

R969.3

韦元元, 栗芳, 陶小妹, 顾红燕. 呼吸科抗菌药物不良反应报告分析和防范措施[J]. 中国药物警戒, 2021, 18(11): 1083-1086.

WEI Yuanyuan, LI Fang, TAO Xiaomei, GU Hongyan. Prevention of Adverse Reactions of Antibiotics in a Respiratory Department[J]. Chinese Journal of Pharmacovigilance, 2021, 18(11): 1083-1086.

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呼吸科抗菌药物不良反应报告分析和防范措施

Prevention of Adverse Reactions of Antibiotics in a Respiratory Department

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