伏立康唑片引起幻视和幻觉不良反应2例及相关文献回顾

doi:10.19803/j.1672-8629.2021.06.20

中国药物警戒 ›› 2021, Vol. 18 ›› Issue (6): 588-591.
DOI: 10.19803/j.1672-8629.2021.06.20

伏立康唑片引起幻视和幻觉不良反应2例及相关文献回顾

张晓娟¹, 杨宏昕¹, 郭小彬¹, 解沛涛^2,*

¹内蒙古自治区人民医院药学处,内蒙古呼和浩特 010010;
²鄂尔多斯市中心医院药剂科,内蒙古鄂尔多斯 017000

收稿日期:2020-05-17 出版日期:2021-06-15 发布日期:2021-07-02
通讯作者: ^*解沛涛,男,主管药师,临床药学。E-mail:xiepeitao57@163.com
作者简介:张晓娟,女,主管药师,临床药学。

Adverse Reactions of Visual Disturbances and Hallucinations Induced by Voriconazole Tablets in Two Cases and Related Literature Review

ZHANG Xiaojuan¹, YANG Hongxin¹, GUO Xiaobin¹, JIE Peitao^2,*

¹Department of Pharmacy, Inner Mongolia People's Hospital, Huhhot Inner Mongolia 010010, China;
²Department of Pharmacy, Ordos Central Hospital, Ordos Inner Mongolia 017000, China

Received:2020-05-17 Online:2021-06-15 Published:2021-07-02

摘要/Abstract

摘要： 目的对伏立康唑引起的幻视和幻觉不良反应的发生规律进行总结,为医务人员安全合理用药提供参考。方法通过分析我院发生的2例伏立康唑引起幻视和幻觉不良反应,查阅国内外相关文献,对伏立康唑引起的幻视和幻觉不良反应的发生概率、发生时间、发生机制、与血药浓度的关联性及转归等方面进行文献回顾。结果伏立康唑引起的视觉毒性和神经系统毒性不良反应的发生概率较其他抗真菌药大;发生不良反应的时间主要在给药的前5 d;神经系统毒性与浓度相关,视觉毒性与浓度没有显著相关性;发生不良反应后及时停药预后较良好。结论伏立康唑发生不良反应的时间主要在给药的前5 d,及时停药预后较良好。

关键词: 伏立康唑, 幻视幻觉, 药品不良反应

Abstract: Objective To summarize the regularity of such adverse reactions as visual disturbances and hallucination caused by voriconazole, and to provide reference for the safe and rational use of medicine by health care givers. Methods Two cases of visual disturbances and hallucinations caused by voriconazole in our hospital were reviewed. The chance, onset time, mechanism, correlations with blood concentration and outcomes of adverse reactions caused by voriconazole were studied. Results Voriconazole was more likely to cause visual toxicity and neurotoxic side effects than other antifungal drugs. Adverse reactions occurred mainly within the first five days of administration. There was a significant correlation between neurotoxicity and concentrations, but there was no significant correlation between visual toxicity and concentrations. Immediate discontinuation of the drug after the occurrence of adverse reactions could lead to good prognosis. Conclusion The adverse reactions to voriconazole mostly occur in the first five days of administration, and the prognosis is better if the drug is discontinued quickly.

Key words: voriconazole, visual disturbances and hallucinations, adverse drug reactions

中图分类号:

R994.11

张晓娟, 杨宏昕, 郭小彬, 解沛涛. 伏立康唑片引起幻视和幻觉不良反应2例及相关文献回顾[J]. 中国药物警戒, 2021, 18(6): 588-591.

ZHANG Xiaojuan, YANG Hongxin, GUO Xiaobin, JIE Peitao. Adverse Reactions of Visual Disturbances and Hallucinations Induced by Voriconazole Tablets in Two Cases and Related Literature Review[J]. Chinese Journal of Pharmacovigilance, 2021, 18(6): 588-591.

参考文献

[1] Walsh TJ, Pappas P, Winston DJ, et al.Voriconazole compared with liposomal amphotericin B for empirical antifungal therapy in patients with neutropenia and persistent fever[J]. N Engl J Med, 2002, 346(4): 225-234.
[2] Qian YY, Xu WY.Analysis of adverse reactions caused by yoriconazole in 36 cases[J]. Zhejiang Medical Education(浙江医学教育), 2018, 17(3): 61-63.
[3] Zheng FY, Wu Y, Rao YF, et al.The role of Knott’s assessment scale in the evaluation of adverse drug reactions and case analysis[J]. Chinese Pharmaceutical Journal(中国药学杂志), 2012, 47(8): 650-652.
[4] Zonios DI, Gea-Banacloche J, Childs R, et al.Hallucinations during voriconazole therapy[J]. Clin Infect Dis, 2008, 47(1): e7-e10.
[5] Xing Y, Chen L, Feng Y, et al.Meta-analysis of the safety of voriconazole in definitive, empirical, and prophylactic therapies for invasive fungal infections[J]. BMC Infect Dis, 2017, 17(1): 798.
[6] Qi YL.Severe psychotic symptoms and limb muscle tension caused by voriconazole in one patients[J]. Chinese Journal of Pharmacovigilance(中国药物警戒), 2013, 10(10): 636-636, 638.
[7] Wang Y, Cui XL, Liu LH.One case of mental abnormality induced by drug interaction[J]. Chinese Journal of Pharmacovigilance(中国药物警戒), 2018, 15(8): 499-500, 505.
[8] Zou JL.Analysis of 31 adverse drug reaction/event cases induced by voriconazole[J]. Chinese Journal of Pharmacovigilance(中国药物警戒), 2013, 10(10): 623-626.
[9] Bayhan GI, Garipardic M, Karaman K, et al.Voriconazole-associated visual disturbances and hallucinations[J]. Cutan Ocul Toxicol, 2016, 35(1): 80-82.
[10] Kinoshita J, Iwata N, Ohba M, et al.Mechanism of voriconazole-induced transient visual disturbance: reversible dysfunction of retinal ON-bipolar cells in monkeys[J]. Invest Ophthalmol Vis Sci, 2011, 52(8): 5058-5063.
[11] Gautierveyret E, Fonrose X, Tonini J, et al.Variability of voricon-azole plasma concentrations after allogeneic hematopoietic stem cell transplantation: impact of cytochrome p450 polymorphisms and comedications on initial and subsequent trough levels[J]. Antimicrob Agents Chemother, 2015, 59(4): 2305-2314.
[12] Jin H, Wang T, Falcione BA, et al.Trough concentration of voriconazole and its relationship with efficacy and safety: a systematic review and meta-analysis[J]. J Antimicrob Chemother, 2016, 71(7): 1772-1785.
[13] Boyd AE, Modi S, Howard SJ, et al.Adverse reactions to voriconazole[J]. Clin Infect Dis, 2004, 39(8): 1241-1244.
[14] Sakurada H, Yasuhara K, Kato K, et al.An investigation of visual hallucinations associated with voriconazole administration to patients with hematological malignancies[J]. Pharmazie, 2016, 71(11): 660-664.
[15] Imhof A, Schaer DJ, Schanz U, et al.Neurological adverse events to voriconazole: evidence for therapeutic drug monitoring[J]. Swiss Med Wkly, 2006, 136(45-46): 739-742.
[16] Eiden C, Peyrière H, Cociglio M, et al.Adverse effects of voriconazole: analysis of the French pharmacovigilance database[J]. Ann Pharmacother, 2007, 41(5): 755-763.
[17] Pasqualotto AC, Xavier Mo, Andreolla HF, et al.Voriconazole therapeutic drug monitoring: focus on safety[J]. Expert Opin Drug Saf, 2010, 9(1): 125-137.
[18] Shao H, Yuan HZ, Jiang JJ. One case of seizure induced by voriconazole for injection[J]. Chinese Journal of Pharmacovigilance(中国药物警戒), 2019, 16(3): 62, 64.
[19] Yang XN, Zhang XY, Wang YQ, et al.Discussion on the relationship between voriconazole drug adverse reactions and clinical intervention measures based on blood drug concentration[J]. The Journal of Nanjing Medical University(Natural Sciences) [南京医科大学学报(自然科学版)], 2018, 38(8):1144-1147.

伏立康唑片引起幻视和幻觉不良反应2例及相关文献回顾

Adverse Reactions of Visual Disturbances and Hallucinations Induced by Voriconazole Tablets in Two Cases and Related Literature Review

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