中国药物警戒 ›› 2020, Vol. 17 ›› Issue (12): 917-920.
DOI: 10.19803/j.1672-8629.2020.12.15

• 安全与合理用药 • 上一篇    下一篇

普外科住院患者头孢菌素类药品不良反应及其影响因素分析

陈燕芳1, 王义桥2*   

  1. 1安徽省第二人民医院第一手术室,安徽 合肥 230001;
    2 安徽省第二人民医院麻醉科,安徽 合肥 230001
  • 收稿日期:2019-10-21 修回日期:2020-12-07 出版日期:2020-12-15 发布日期:2020-12-07
  • 通讯作者: *王义桥,男,博士,主任医师,麻醉学相关药品安全性分析及评价。E-mail:cxcdy7@163.com
  • 作者简介:陈燕芳,女,本科,主管护师,围手术期药品安全性的监测分析与评价。

Adverse Drug Reactions of Cephalosporins and Influencing Factors in Hospitalized Patients for General Surgery

CHEN Yanfang1, WANG Yiqiao2*   

  1. 1The First Operating Room of Anhui Second People's Hospital,Hefei Anhui 230001,China;
    2Department of Anesthesiology,Anhui Second People's Hospital,Hefei Anhui 230001,China
  • Received:2019-10-21 Revised:2020-12-07 Online:2020-12-15 Published:2020-12-07

PDF (PC)

120

摘要： 目的 分析普外科常用头孢菌素类药品不良反应(ADR)及影响因素,通过针对性预防,保障患者用药安全。方法 随机选取2017年1月至2019年11月普外科246例应用头孢菌素类药品的住院患者病例资料进行回顾性分析。结果 头孢菌素类ADR涉及皮肤及附件损害、消化系统损害、中枢神经系统反应等;给药途径以静脉注射为主;ADR多在用药1 h内发生;患者年龄、过敏史、合并用药、给药途径等在ADR发生中差异有统计学意义(P<0.05),但在性别、体重、原患疾病上差异无统计学意义(P>0.05)。结论 年龄大于60岁、有过敏史、联合用药、静脉给药是头孢菌素类ADR的危险因素。临床用药时应当详细评估患者是否存在发生ADR的危险因素,最大限度保证头孢菌素类药品的合理使用,掌握ADR的对症治疗与抢救措施,保证患者用药安全。

关键词: 头孢菌素, 抗菌药物, 药品不良反应, 影响因素, 分析

Abstract: Objective To study the adverse drug reactions and influencing factors of cephalosporins in the perioperative period and seek targeted prevention in order to ensure the safety of patients.Methods A total of 246 medical records of patients with cephalosporins admitted to our hospital between January in 2017 and November in 2019 were randomly selected for retrospective analysis.Results The adverse drug reactions of cephalosporins involved the skin and accessory damage, digestive system damage, and central nervous system reactions. The main route of administration was intravenous injection and adverse drug reactions usually occurred within 1 hour of administration. There was statistically significant difference in the occurrence of adverse drug reactions between patients who were different in age, allergy history, concomitant medications, and routes of administration(P<0.05), but no significant difference was found in gender,weight or primary diseases between the ADR group and the non-ADR group (P>0.05).Conclusion Age above 60 years, a history of allergies, combined medications and intravenous administration are risk factors for adverse drug reactions of cephalosporins. During clinical medication, patients should be carefully evaluated for risk factors for adverse drug reactions to ensure the proper use of cephalosporins. Symptomatic treatment and rescue measures are critical to control of adverse drug reactions.

Key words: cephalosporins, antibacterial drugs, adverse drug reaction, influencing factor, analysis

中图分类号: