巴氯芬致肾功能不全者不良反应文献分析

doi:10.19803/j.1672-8629.2020.05.08

摘要/Abstract

摘要： 目的讨论巴氯芬在肾功能不全者中使用发生药品不良反应的规律和特点,为临床合理用药提供参考。方法检索1990~2018年中国学术期刊全文数据库、维普中文科技期刊数据库及Pubmed、Wiley、EBSCO等数据库,收集肾功能不全者服用巴氯芬发生不良反应的文献,进行统计分析。结果本研究纳入31篇文献,共有患者48例,其中男性28例（58.33%）,女性20例（41.67%）,年龄≥60岁的老年患者29例（61.70%）,终末期肾病43例（89.58%）。不良反应主要发生在用药4天内（77.08%）,每日用药剂量为5~40 mg。临床主要表现为嗜睡、意识不清、昏迷。48例不良反应患者中,有4例（8.33%）停药后症状好转,6例（12.50%）行腹膜透析,38例（79.17%）行血液透析后症状好转。结论巴氯芬在肾功能不全者中使用容易出现中枢神经系统不良反应,临床应谨慎使用,密切监测。

关键词: 巴氯芬, 肾功能不全, 不良反应

Abstract: Objective To explore the regularities and characteristics of adverse reactions induced by baclofen in patients with renal insufficiency so as to provide reference for rational clinical use of this drug. Methods The CNKI, VIP, Pubmed, Wiley and EBSCO database were searched to retrieve related articles published between 1990 and 2018 . The clinical data of baclofen induced adverse reactions in patients with renal diseases was collected and statistically analyzed. Results A total of thirty-one pieces of literature involving forty-eight cases were enrolled for analysis. The patients comprised twenty-eight males (58.33%) and twenty females (41.67%). Twenty-nine of them (61.70%) were above 60 and 43 of them (89.58%) were patients with ESRD. The adverse drug reactions induced by baclofen usually started within four days (77.08%). The daily dose of baclofen ranged from 5mg to 30mg. The major clinical manifestations were drowsiness, unconsciousness and coma. Of the forty-eight patients, four (8.33%)improved after drug discontinuation, six (12.50%) improved after peritoneal dialysis, and thirty-eight (79.17%) improved after hemodialysis. Conclusion Baclofen can lead to adverse drug reactions in the central nervous system of patients with renal insufficiency. Careful assessment of risk versus benefit is required when baclofen is used for patients with kidney disease. Patients taking baclofen must be monitored.

Key words: baclofen, renal insufficiency, adverse drug reactions

中图分类号:

R978.7

赵敏, 黄振光. 巴氯芬致肾功能不全者不良反应文献分析[J]. 中国药物警戒, 2020, 17(5): 296-299.

ZHAO Min, HUANG Zhenguang. Literature Review of Baclofen-induced Adverse Reactions in Patients with Renal Insufficiency[J]. Chinese Journal of Pharmacovigilance, 2020, 17(5): 296-299.

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