The critical role of TRP channels in the progression of viral pneumonia

doi:10.19803/j.1672-8629.20230618

Abstract

Abstract: Objective To conduct a comprehensive review of the potential mechanisms of occurrence between viral pneumonia infection and the TRP channel family. Methods By searching CNKI and PubMed, the reports from the past 30 years on the relationship between the TRP channel family and viral pneumonia, as well were as discussions the underlying mechanisms were discussed. Results As ion receptor channels on the cell membrane, TRP channels can regulate the balance of calcium ions inside and outside the cell, inhibiting or accelerating virus invasion into the host. By accelerating the influx of calcium ions, they intensify cellular oxidative stress responses, speeding up cell autophagy or apoptosis. Additionally, by promoting changes in cell morphology, they enhance the cell’s response to inflammatory mediators and cytokines. Conclusion TRP channels are crucial regulatory factors in the process of viral infection of hosts, exerting direct or indirect effects on various physiological processes during the infection. Therefore, a deeper study of the TRP channel family can offer new targets for antiviral drug development, providing fresh perspectives for clinical treatment of viral pneumonia.

Key words: pneumonia, viral pneumonia, transient receptor potential channels, ion, cell

CLC Number:

BAO Lei, GENG Zihan, LI Shuran, JI Zuen, ZHAO Ronghua, SUN Jing, GUO Shanshan, CUI Xiaolan. The critical role of TRP channels in the progression of viral pneumonia[J]. Chinese Journal of Pharmacovigilance, 2024, 21(2): 137-140.

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