Abstract: Objective To investigate the characteristics of anaphylactic shock induced by fluticasone furoate in order to provide reference for clinical safe and rational drug use. Methods One case of anaphylactic shock caused by the use of fluticasone furoate and treated in our hospital was analyzed. The correlations between anaphylactic shock and the suspected drug were studied using the Knoop’s adverse reaction score. The causes and mechanisms of anaphylactic shock caused by fluticasone furoate were studied by reviewing literature. Results According to the patient’s medical history, the correlation score of adverse reactions of fluticasone furoate was 5 points (possibly related). It was likely that allergic shock was caused by fluticasone furoate, or rather, by the adjuvant milk protein contained, but it was also possible that the main ingredient - umeclidinium bromide-was also involved. Conclusion Patients with a history of milk protein allergy should be routinely inquired about their allergy history, and the use of inhaled powder or other drugs containing milk protein as excipients should be avoided so as to prevent serious allergic reactions.

Key words: fluticasone furoate, adjuvant, powder for inhalation, anaphylactic shock, lactose protein