Abstract: Objective To establish a method based on the weighted technique for order preference by similarity to ideal solution(TOPSIS) method to assess the usage of linezolid by a pediatric department, and to provide reference for rational use of linezolid for pediatric patients. Methods Based on instructions about linezolid, expert consensus, related guidelines for diagnosis and treatment, and the TOPSIS method, explicit rules for assessment of the ways in which linezolid was prescribed by a pediatric department were established before the usage of linezolid among 57 pediatric patients in Anqing First People's Hospital between September 1, 2020 and March 31, 2021 was assessed. Results Among the 57 cases, the relative approach degree was 100% in two cases(3.51%), ranged from 80% to less than 100% in three cases (5.26%), from 60% to less than 80% in thirty-six cases (63.16%), from 50% to less than 60% in sixteen cases (28.07%), and was 60% or above in 41 cases (71.93%). Conclusion The weighted TOPSIS method can be used to assess the usage of linezolid among pediatric patients. The results of assessment suggest that linezolid has been properly used in our hospital, but the rational use can be standardized in terms of consultations, duration of medication, evaluation of efficacy and monitoring of drug adverse reactions.

Key words: linezolid, weighted TOPSIS method, drug use evaluation, a pediatric department