Abstract: Objective To explore the influencing factors of suspected allergic reactions caused by cervus and cucumis polypeptide for injection in the real world. Methods The study was based on information about patients who had used cervus and cucumis polypeptide for injection in the hospital information system of 26 large-scale tertiary hospitals in China from July 1, 2003 to December 31, 2014. A retrospective nested case-control study was conducted to compare the group of suspected allergic patients with the group of non-allergic patients. The logistic regression method was used to analyze the influencing factors of suspected allergic reactions based on such information as complications, combined medications, length of hospital stay, courses of medication and dosage. Results A total of 5 745 cases were included in this study, including 1 149 suspected allergic reactions (the allergic group) and 4 596 patients who had not developed any allergic reactions (the control group). Logistic regression analysis found that complications, combined medications, length of hospital stay, courses of medication and single dose had no significant effect on the incidence of suspected allergic reactions caused by cervus and cucumis polypeptide for injection. However, the difference was statistically significant when cervus and cucumis polypeptide for injection was combined with norfloxacin (P=0.011 3). Conclusion The combined use with norfloxacin may be a determinant of suspected allergic reactions related to cervus and cucumis polypeptide for injection (P<0.05). Which provides a reference to the rational use of drugs in clinic.

Key words: cervus and cucumis polypeptide for injection, suspected allergic reaction, influencing factors, real world