Abstract: Objective To analyze antibiotic encephalopathy caused by ceftriaxone sodium in patients under renal dialysis, and to provide reference for clinical drug use among a special population. Methods The clinical data on three dialysis patients with psychiatric symptoms caused by ceftriaxone sodium was analyzed by a clinical pharmacist according to the correlation evaluation criteria established by the National Center for Adverse Drug Reactions and the Naranjo's Adverse Drug Evaluation Scale. Results After ceftriaxone sodium was used, all the three patients experienced different degrees of psychotic symptoms. But when antibacterial drugs were discontinued and symptomatic treatment started, these mental symptoms were alleviated. Conclusion For patients with renal insufficiency, cephalosporins should be used with caution to prevent psychiatric abnormalities that are not included in the instructions, which occasionally occur and need to be taken seriously by clinicians.

Key words: ceftriaxone sodium, chronic kidney disease, dialysis, antibiotic encephalopathy