112 Cases of Hypersensitivity Induced by Methylprednisolone Sodium Succinate

doi:10.19803/j.1672-8629.2021.02.12

Abstract

Abstract: Objective To investigate the characteristics and regularity of hypersensitivity caused by methylprednisolone sodium succinate in order to provide reference for rational clinical use of drugs. Methods The data on 112 cases of ADRs induced by methylprednisolone sodium succinate that was collected by Weifang Center for ADR Monitoring between January 2013 and October 2019 was analyzed. Results Among the 112 patients, the ratio of males to females was 1.6:1, and 66.07% of them were 0-3 years old. The preexisting diseases mostly involved the respiratory system, accounting for 67.87% of the total. The most common manifestations of hypersensitivity were the damage to the skin and its accessories (74.63%). Meanwhile, 96.43% of the ADRs occurred on the day of administration, and 71.43% within 30 minutes. In the end, 110 patients were improved/cured after symptomatic treatment. Conclusion The hypersensitivity induced by methylprednisolone sodium succinate deserves more attention. Administration should be discontinued soon after ADRs occur and symptomatic treatment should start without delay.

Key words: methylprednisolone sodium succinate, hypersensitivity, rational use of drugs

CLC Number:

R994.11

CHEN Huanlei, LI Ning, ZHENG Xueling. 112 Cases of Hypersensitivity Induced by Methylprednisolone Sodium Succinate[J]. Chinese Journal of Pharmacovigilance, 2021, 18(2): 155-159.

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