Abstract: Objective To analyze the reports of adverse drug reactions(ADR) in the neuropsychiatric system caused by zolpidem, and explore the characteristics and patterns of adverse reactions, and to promote rational use of new hypnotic drugs in clinical practice. Methods Six cases of neuropsychiatric ADR caused by zolpidem reported in our hospital from January 1, 2004 to December 31, 2021 were selected and analyzed. Medications, ADR, treatments and outcomes of the patients were analyzed. The characteristics of neuropsychiatric ADR caused by zolpidem were studied. Results All the six patients were female. Most of the patients had adverse reactions soon after taking zolpidem. ADR occurred on the very night this drug was taken in most patients, and only one case of amnesia occurred on the 5^th day after taking the drug. The clinical manifestations of adverse reactions included the inability to recall the abnormal behavior of the previous night and unclear consciousness. After the onset of adverse reactions, the patients discontinued this drug and shifted to other sedative and hypnotic drugs, and the symptoms were relieved or returned to normal. Conclusion ADR of the nervous system caused by zolpidem, delirium and suspected delirium make up a large proportion. There are still the chances of adverse reactions at normal daily doses. Women may be more prone to neuropsychiatric ADR after taking zolpidem, and adverse reactions should be closely monitored at the beginning of treatment, especially on the night of treatment. The indications of drugs should be kept in mind in clinical practice to ensure the safety of drug use.

Key words: zolpidem, the nervous system (CNS), the mental system, adverse drug reaction(ADR), rational use of drugs