Chinese Journal of Pharmacovigilance ›› 2020, Vol. 17 ›› Issue (5): 308-310.
DOI: 10.19803/j.1672-8629.2020.05.11

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One Case of Liver Injury Induced by Mycophenolate Mofetil Dispersible Tablets

YIN Tong1, WANG Yaochen2, NI Xiaojun3*   

  1. 1 The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei Anhui 230000, China;
    2 Department of Pharmacy, The First people's hospital of LianYunGang, LianYunGang Jiangsu 222000, China;
    3 Department of Pharmacy, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200000, China
  • Received:2019-07-11 Revised:2020-06-22 Online:2020-05-15 Published:2020-05-13

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Abstract: ObjectiveTo analyze such adverse effects of mycophenolate mofetil dispersible tablets as drug-induced liver injury. Methods The clinical data on one case of elevation of hepatic enzymes after taking mycophenolate mofetil dispersible tablets in Shanghai Renji Hospital in December 2019 was summarized. Results The patient complained about progressive vision loss of more than 2 months. She was diagnosed with neuromyelitis optica spectrum disorders. Hepatic enzymes gradually increased 5 days after taking mycophenolate mofetil dispersible tablets (0.25 g/d). The peak value was 350 U/L for alanine aminotransferase (ALT), 161 U/L for aspartate aminotransferase (AST), 126 U/L for lactate dehydrogenase (LDH), 63 U/L for alkaline phosphatase (ALP), and 25 U/L for γ-L-glutamyltranspeptidase (γ-GT). After mycophenolate mofetil dispersible tablets were discontinued, hepatoprotective treatment was given. During the revisit 5 days later, her hepatic function returned to normal. Conclusion Mycophenolate mofetil has adverse effects, such as drug-induced liver injury.

Key words: mycophenolate mofetil, drug induced liver injury

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