Abstract: Objective To investigate the perception ability of risk on drug induced progressive multifocal leukoencephalopathy (PML) in China, and to provide support to treat and prevent PML reasonably. Methods The literatures in domestic and overseas bibliographic databases, the individual adverse drug reaction cases in Vigibase and China adverse drug reaction database were analyzed. Results Health professionals and Regulators in other countries have paid great attention on the diagnose, individual cases report and risk management of drug induced PML. But in our country, the perception of risk on drug induced PML is insufficient. Conclusion The risk of drug induced PML will exist for a long time, while the monitoring ability in our country lags behind other countries. In order to improve the monitoring and risk management ability on drug induced PML, several departments, such as manufactures, health professionals and regulators need to do more efforts and communication.

Key words: drug induced, progressive multifocal leukoencephalopathy, perception of risk