Chinese Journal of Pharmacovigilance ›› 2016, Vol. 13 ›› Issue (5): 263-265.

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Analysis of Efficacy of S-1 Capsale Monotherapy Third-line Treatment in Elderly Patients with Advanced Colorectal Cancer

LV Jian-hua, LV Jian-li, LI Yong-bing   

  1. Puyang People'
    s Hospital, Henan Puyang 457000, China
  • Received:2015-06-02 Revised:2016-06-30 Online:2016-05-20 Published:2016-06-30

Abstract: Objective To investigate the clinical efficacy of S-1 monotherapy third-line treatment in elderly patients with advanced colorectal cancer. Methods 66 cases of senile advanced colorectal cancer patients were selected in our hospital from August 2013 to August 2014, who were randomly divided into the observation group and the control group with 33 cases in each group. In observation group, third-line S-1 monotherapy was applicated, while the patients in control group were treated with capecitabine tablets. The efficacy and side effects of the drugs were observed and compared between the two groups of patients. Results In the observation group patients, the clinical effective rate was 45.45%, while it was 42.42% in the control group. There was no significant difference (P > 0.05) between the two groups of patients. Improvement of KPS score in the observation group was significantly higher than that of the control group with significant difference between the two groups (P < 0.05).Diarrhea and hand foot syndrom incidence in observation group was significantly lower than that of the control group, which was significantly different (P < 0.05). Conclusion In elderly patients with advanced colorectal cancer, S-1 capsule monotherapy third-line treatment is effective with less adverse reactions and dosing convenience. It can improve the life quality of patients, also with a higher tolerance. It is worthy to be further applicated and promoted in clinic.

Key words: advanced colorectal cancer, elderly patient, S-1 capsule

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