Abstract: Objective To evaluate the effects of arctigenin injection（NBZGY）on the cardiovascular system and the respiratory system by subcutaneous administration in conscious Beagle dogs that implanted with telemetry transmitters. Methods Eight Beagle dogs with telemetry transmitters（TL11M2-D70-PCTR）were subcutaneously administrated with NBZGY injection (0.05~5 mg·kg^-1) and 30% PEG (normal control). All dogs received normal control and NBZGY injection in sequence every other day. The ECG (RR interval, heart rate, T wave, ST segment, QRS interval, PR interval, QT interval), body temperature, blood pressure (systolic blood pressure, diastolic blood pressure, mean blood pressure) and respiratory (tidal volume, respiratory rate) data were continuously monitored for at least 2 h before dosing and 1, 1.5, 2, 3, 4, 5, 6, 12 and 24 h after dosing. Results Compared with the vehicle control group at 1, 2, 24 h after dosing, tidal volume, respiratory rate increased significantly（P<0.05）, RR interval,diastolic blood pressure, mean blood pressure reduced significantly（P<0.05）. Conclusion Under these study condictions,no obvious change in the cardiovascular system and the respiratory system of Beagle dogs was found after subcutaneous administration with NBZGY.

Key words: telemetry system, arctigenin injection, cardiovascular system, respiratory system