Effects of Baicalin on Activity of Influenza A Virus RNA Polymerase by Silencing Host Factors PACT

Chinese Journal of Pharmacovigilance ›› 2016, Vol. 13 ›› Issue (3): 129-131.

Effects of Baicalin on Activity of Influenza A Virus RNA Polymerase by Silencing Host Factors PACT

GUO Shan-shan, BAO Lei, CUI Xiao-lan

Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100029, China

Received:2006-01-11 Revised:2016-04-12 Online:2016-03-20 Published:2016-04-12

Abstract

Abstract: Objective To observe effects of baicalin on influenza A virus RNA polymerase before and after silencing the PACT protein. Methods Dual luciferase reporter gene approach was used to detect relative expression of influenza A virus polymerase in 293T cells, and judge the influence of influenza A virus polymerase by treatment with baicalin before and after silencing the PACT protein. Results Baicalin could decrease the relative expression of influenza A virus RNA polymerase, and the effects were more obvious by silencing the host factors PACT. Conclusion Silencing the PACT protein and treating with baicalin can reduce the activity of influenza A virus RNA polymerase.

Key words: baicalin, host factors PACT, influenza A virus RNA polymerase

CLC Number:

R965
R285.5

GUO Shan-shan, BAO Lei, CUI Xiao-lan. Effects of Baicalin on Activity of Influenza A Virus RNA Polymerase by Silencing Host Factors PACT[J]. Chinese Journal of Pharmacovigilance, 2016, 13(3): 129-131.

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