Abstract: Objective To optimize the best drying and molding technology of Qianliean concentrated pills. Methods Orthogonal test was employed for selecting the optimum drying technology of Qianliean concentrated pills by the content of salvianolic acid B and water content score, the factors to consider include the concentration ratio, drying temperature, drying time and vacuum degree. The molding technology was optimized with the molding rate and the time of disintegration score as index, and with the cutting speed, pushing time, concentration of ethanol and amount of alcohol as the factors. Results The best drying technology conditions were as follows: the concentration ratio was 1: 1.3, drying temperature was 65 ℃ , drying time was 60 min and vacuum degree was 0.08 MPa. Meanwhile, the factors of optimum molding technology were that when the concentration of ethanol was 80%, the cutting speed was 30 rpm, the pushing speed was 30 rpm and the amount of ethanol was 10%. Conclusion The optimized process is simple, feasible and stable, which can be used for the mass production of Qianliean concentrated pills.

Key words: Qianliean concentrated pills, microwave vacuum, drying technology, salvianolic acid B, molding technology