Preparation and in Vitro Release and in Vivo Pharmacokinetics Evaluation of Ambroxol Hydrochloride-resin Complex Sustained Release Suspension

Chinese Journal of Pharmacovigilance ›› 2017, Vol. 14 ›› Issue (1): 22-26.

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Preparation and in Vitro Release and in Vivo Pharmacokinetics Evaluation of Ambroxol Hydrochloride-resin Complex Sustained Release Suspension

ZHANG Yong-e, ZHANG Xue-nong^*

College of Pharmaceutical Science, Soochow University, Jiangsu Suzhou 215006, China

Received:2016-10-27 Revised:2017-02-16 Online:2017-01-20 Published:2017-02-16
Contact: 张学农,男,博士,教授,靶向递药系统和缓控释新材料与新技术。E-mail：zhangxuenong@163.com

Abstract

Abstract: ObjectiveTo prepare the ambroxol hydrochloride-resin complex sustained release suspension and evaluate its in vitro release and in vivo pharmacokinetics. MethodsThe sustained release suspension was prepared by resin optimization, saturation, file coating and dispersion of the complex. Evaluation of the in vitro and in vivo performance of the suspension was carried out. ResultsThe ambroxol hydrochloride-resin complex suspension had similar release behavior and pharmacokinetic parameters with the sustained release capsule product. ConclusionThe resin complex suspension would be another sustained release drug delivery system for ambroxol hydrochloride.

Key words: ambroxol hydrochloride, ion exchange resin, sustained-release suspension, in vitro release, pharmacokinetics evaluation

CLC Number:

R945

ZHANG Yong-e, ZHANG Xue-nong. Preparation and in Vitro Release and in Vivo Pharmacokinetics Evaluation of Ambroxol Hydrochloride-resin Complex Sustained Release Suspension[J]. Chinese Journal of Pharmacovigilance, 2017, 14(1): 22-26.

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Preparation and in Vitro Release and in Vivo Pharmacokinetics Evaluation of Ambroxol Hydrochloride-resin Complex Sustained Release Suspension

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