Abstract: Objective To explore the clinic features and regularity of allergic reactions caused by copper containing intrauterine devices(IUD), so as to provide a reference for clinical diagnosis and treatment. Methods Allergic reactions caused by IUD reported in CNKI, VIP, Wanfang databases were collected and analyzed statistically. Results Copper containing IUD related allergic reactions generally occurred in women who first use it especially in those who have a history of allergy in clinics, but it was not related to the copper surface or the shape of IUD. The allergic reactions mostly occurred in maternity care or family planning institutions, and involved multiple organs and systems. The clinical manifestations were various. There were also some symptoms of the reproductive system specifically. If allergic reactions were diagnosed, to take out the IUD and all symptoms would disappear in a short time. Conclusion Doctors should be careful to ask the women about the history of allergy before placing IUD, and to prepare first aid and to master the technology of treating acute allergy. In addition, if a similar allergic reaction was encountered in the clinic, the possibility for IUD allergic reaction should be considered.

Key words: intrauterine device, allergy, adverse event