Abstract: Objective To research the compatibility of Cervus and Cucumis polypeptide for injection combined with different injections and to provide favorable experimental basis for the clinical application of the Cervus and Cucumis polypeptide for injection. Methods According to the current dosage of clinical medicine, the Cervus and Cucumis polypeptide for injection was added to the sterilized water for injection as control group. Cervus and Cucumis polypeptide for injection was added to 0.9% sodium chloride injection, 5% and 10% glucose injection and glucose-sodium chloride injection as experimental group.The combination solution change of color, pH value, and the number of particles were reseached at 0 h, 0.5 h, 1 h, 2 h, 4 h, 8 h which were detected by the method specified in China Pharmacopeia (2015 edition, No 4). Results The Cervus and Cucumis polypeptide for injection combined with the 0.9% sodium chloride injection solution at different time was light yellow liquid, The pH value remained stable and the number of particles was conforms to the 2015 edition of China Pharmacopoeia standards. The numbers of ≥10µm particles exceeded the limitation of China Pharmacopoeia after combinee with 5% and 10% glucose injection and glucose-sodium chloride injection. There were no significant changes in clarity and pH value. Conclusion The most suitable solvent compatibility for Cervus and Cucumis polypeptide for injection was 0.9% sodium chloride injection. In the clinical application, the transfusion must be slowly infusied and close observation should be given to the patients.

Key words: Cervus and Cucumis polypeptide for injection, injection, compatibility